Clinical trial · Observational
Extracorporeal Carbon Dioxide Removal in Severe Chronic Obstructive Pulmonary Disease Exacerbation
Evaluation of Clinical Effectiveness of ECCO2R for the Treatment of Patients With Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The conventional treatment for Severe acute exacerbation of Chronic obstructive pulmonary disease including noninvasive respiratory support, invasive respiratory support, etc, but there are many kinds of limitations and complications. Extracorporeal Carbon Dioxide Removal is a life support technology, which can effectively remove CO2. Recently some clinical studies have showed that ECCO2R can effectively improve the AECOPD patient's respiratory failure, avoid intubation and removal of endotracheal intubation. We performed a study to evaluate the clinical effectiveness of ECCO2R in the treatment of AECOPD patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| COPD Exacerbation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extracorporeal Carbon Dioxide Removal | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- incidence of avoid endotracheal intubation
- timeFrame
- 30days
- description
- avoid endotracheal intubation and Invasive mechanical ventilation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * NPPV treatment failure: 1. deterioration or no improvement after treatment with NPPV, pH \< 7.25, PaCO2 \> 70mmHg 2. Obvious respiratory distress, RR \> 30 times/min 3. Breathing extreme fatigue Exclusion Criteria: * Older than 75 years * endotracheal intubation or tracheostomy * obviously a lot of pus yellow phlegm, expectorate difficult * Chest CT: obviously a wide range of consolidation * BMI \< 20 kg/m2, * Dysfunction of other organ of extrapulmonary * serious hemodynamic instability * severe hypoxemia, PaO2 / FiO2 \< 100mmHg * home noninvasive positive pressure ventilation for a long time * lung fungal infection * contraindication of anticoagulation * Platelet \< 80000 per cubic millimeter * Serum creatinine \> 200 umol/L * cardiac arrest * Hospice care * Refused to take part in the study
References
Publications (0)
Data not yet available