Clinical trial · Interventional
DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis
Advanced CT Imaging Optimization for the Detection of Intracranial Metastasis
NCT03685539CI-TRIAL-00069226completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies how well dual energy computed tomography (DECT) works in imaging patients with solid organ cancer that has spread to the brain. Imaging techniques, such as DECT, may help find and diagnose tumor cells and find out how far the tumor cells have spread in the brain.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Neoplasm | Malignant Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Metastatic Malignant Neoplasm in the Brain | Brain Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dual-Energy Computed Tomography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (DECT)
- description
- Within 7 days before the standard Gamma Knife MRI, patients undergo DECT scan over 6 seconds at 1.5, 5, 10, and 20 minutes after receiving the contrast agent.
- interventionNames
- Procedure: Dual-Energy Computed Tomography
Primary outcomes (2)
- measure
- Best diagnostic performance of computed tomography (CT) reconstruction parameters
- timeFrame
- Up to 2 years
- description
- A repeated-measures analysis of variance with the Dunnett post hoc test will be used to determine the significance of the differences in the signal-to-noise (SNR) and contrast-to-noise (CNR) measurements at the optimal parameter setting, compared with all other parameter settings.
- measure
- Accuracy of CT
- timeFrame
- Up to 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patient with pathology-proven solid organ cancer * MRI of the brain with contrast, positive for two or more metastatic lesions * One lesion with a single greatest diameter on contrast-enhanced MRI of 1 cm or greater * Planned treatment with stereotactic radiosurgery Exclusion Criteria: * Known allergy to iodine-based contrast agents * Patients with glomerular filtration rate (GFR) less than 30 or use of hemodialysis * If prior nephrectomy, GFR less than 60 * Prior central nervous system malignancy * Prior brain radiation * Pregnant women are excluded
References
Publications (0)
Data not yet available
No reference posted for this study.