Clinical trial · Interventional
Pilot Study of High Risk Lung Cancer Screening
A Prospective Pilot Study of Lung Cancer Screening in Patients at High Risk for Lung Cancer Who Do Not Meet Current Screening Guidelines
NCT03683940CI-TRIAL-00072169completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is a prospective trial of 200 individuals at high risk for lung cancer who are not eligible for lung cancer screening under current screening guidelines.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Screening | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Screening
- description
- Subjects will undergo a low dose non contrast CT chest for lung cancer screening.
- interventionNames
- Diagnostic Test: Screening
Primary outcomes (5)
- measure
- Lung Cancer Screening
- timeFrame
- Duration of the study, up to 3 years
- description
- Prospectively identify patients for lung cancer screening using risk calculators
- measure
- Medical Outcomes
- timeFrame
- Duration of the study, up to 3 years
- description
- Evaluate health outcomes of CT screening by assessing the number and stage of lung cancers detected by screening using Lung-RADS criteria
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 82 Years
Show eligibility criteria text
Inclusion Criteria: 1. Adult 40-82 yrs of age. 2. Presenting for lung cancer screening evaluation. 3. Calculated 6 yr lung cancer risk \>1.5% for patients 40-77 years of age or \>4% for patients 78-82 years of age. 4. Able and willing to provide informed consent. Exclusion Criteria: 1. Eligible for clinically indicated lung cancer screening (55-80 yr old, \>30 pky smoking history, still smoking or quit smoking within the last 15 yr). 2. Chest CT performed within the last year. 3. Life expectancy less than 6 months. 4. Symptoms clinically consistent with lung cancer. 5. Unable or unwilling to undergo treatment for lung cancer. 6. Any individual who does not give oral and written consent for participation.
References
Publications (1)
- DERIVEDHirsch EA, New ML, Brown SL, Malkoski SP. Results of a pilot risk-based lung cancer screening study: outcomes and comparisons to a Medicare eligible cohort. Discov Oncol. 2023 Aug 29;14(1):160. doi: 10.1007/s12672-023-00773-5. PMID 37642787