Clinical trial · Interventional
Validation of Low Dose CT for Diagnosis of Lung Nodules
Validation of an Extremely Low Dose Computed Tomography Protocol for Diagnosing Lung Nodules in Children and Young Adults
NCT03681873CI-TRIAL-00060327completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators have developed an extremely low dose computed tomography (CT) protocol that on preliminary testing has an effective dose in the range of two chest radiographs. The investigators plan to test this exam in patients with known or suspected cancer undergoing clinically indicated chest CT.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Metastasis to Lung | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extremely Low Dose CT | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Study Group
- description
- Patients will receive both the clinically indicated and extremely low dose exams
- interventionNames
- Diagnostic Test: Extremely Low Dose CT
Primary outcomes (1)
- measure
- Diagnostic performance of extremely low dose CT
- timeFrame
- At time of imaging
- description
- Sensitivity
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 4 Years
- Maximum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Pediatric and young adult patients (ages 4 to \<21 years) * Known or suspected malignancy other than lymphoma * Undergoing clinically indicated CT of the chest Exclusion Criteria: * Pregnancy identified by routine Department of Radiology verbal screening * Prior enrollment in the same study (no patient will be enrolled more than once) * Inability to provide consent and/or assent * Lymphoma
References
Publications (2)
- DERIVEDHardie RC, Trout AT, Dillman JR, Narayanan BN, Tanimoto AA. Performance of Lung Nodule Computer-Aided Detection Systems on Standard-Dose and Low-Dose Pediatric CT Scans: An Intraindividual Comparison. AJR Am J Roentgenol. 2025 Jan;224(1):e2431972. doi: 10.2214/AJR.24.31972. Epub 2024 Oct 9. PMID 39382534
- DERIVEDThapaliya S, Gilligan LA, Brady SL, Anton CG, Crotty EJ, Nasser MP, Geller JI, Pressey JG, Zhang B, Dillman JR, Trout AT. Comparison of 0.3-mSv CT to Standard-Dose CT for Detection of Lung Nodules in Children and Young Adults With Cancer. AJR Am J Roentgenol. 2021 Dec;217(6):1444-1451. doi: 10.2214/AJR.21.26183. Epub 2021 Jul 7. PMID 34232694