Clinical trial · Interventional
Effect of Exercise on Cardiometabolic Profile in Women With Polycystic Ovary Syndrome
Effects of Exercise on Oxidised LDL and Cardiometabolic Profile in Women With Polycystic Ovary Syndrome: Study Protocol for a Feasibility Randomized-controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Polycystic Ovary Syndrome (PCOS) is a complex hormonal and metabolic disorder that has been shown to affect women's fertility. It can also share many symptoms with pre-diabetes, and women with PCOS often have an increased risk for type 2 diabetes, heart attack and stroke. This study aims to assess the feasibility and acceptability of exercise intervention and increased lifestyle physical activity to improve cardiovascular disease risk factors in women with PCOS.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Intervention | Behavioral | — | UNRESOLVED |
| Lifestyle Physical Activity | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Exercise Intervention
- description
- Structured exercise intervention will be undertaken for 12 weeks
- interventionNames
- Behavioral: Exercise Intervention
- type
- EXPERIMENTAL
- label
- Lifestyle Physical Activity
- description
- Increased lifestyle physical activity undertaken for 12 weeks
- interventionNames
- Behavioral: Lifestyle Physical Activity
- type
- NO_INTERVENTION
- label
- Control
- description
- Resting control
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women diagnosed with PCOS according to the Rotterdam Criteria 2003, National Institute of Health (NIH) 1990 criteria or Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society 2006 criteria. * Have experienced menarche (their first menstrual bleeding) and be at least 18 years of age. * Are English speaking. * Are physically able to perform exercise. Exclusion Criteria: * Post-menopausal status. * Are smokers. * Are undertaking regular structured exercise defined as \>150min/week. * Have been taking metformin for less than three months. * Are taking the oral contraceptive pill (OCP) or have taken in the last month. * Have any medical condition that may be responsible for the symptoms of PCOS, such as congenital hyperplasia, androgen-secreting tumour, hyperprolactinemia, or Cushing's syndrome. * Have current cardiovascular disease or a history of cardiac events.
References
Publications (1)
- DERIVEDWoodward A, Broom D, Dalton C, Metwally M, Klonizakis M. Supervised exercise training and increased physical activity to reduce cardiovascular disease risk in women with polycystic ovary syndrome: study protocol for a randomized controlled feasibility trial. Trials. 2020 Jan 20;21(1):101. doi: 10.1186/s13063-019-3962-7. PMID 31959233