Home-based Exercise Intervention for Patients With Metastatic Prostate Cancer

Inclusion Criteria:

* Metastatic disease that has progressed despite castrate levels of testosterone (surgically or medically castrated, with testosterone levels of \< 50 ng/dL) receiving ADT. This will be verified by assessing total testosterone levels within 4 weeks prior to enrollment.
* No current chemotherapy.
* Patients may be receiving additional hormonal therapy agents including but not limited to antiandrogens (e.g. bicalutamide, enzalutamide) and CYP17 inhibitors (e.g. abiraterone).
* Ability to engage safely in moderate exercise as determined by their treating physician.
* Not previously engaged in regular exercise training (\<3 or more d/wk for \> 30 min/d or \<90 mins per week total including strength training, aerobic training, or walking) in the past 6 months.
* Access to a computer or a smart phone for syncing and uploading wearable activity data.
* Be able to speak and read English.

Exclusion Criteria:

* Any condition that causes severe pain with exertion.
* History of bone fractures.
* Active cardiovascular disease including any of the following:

  * New York Heart Association (NYHA) Grade II or greater congestive heart failure .
  * History of myocardial infarction or unstable angina within 6 months prior to Day 1.
  * History of stroke or transient ischemic attack within 6 months prior to Day 1.
* Acute or chronic respiratory disease that is severe enough to compromise the ability of the participant to safely engage in exercise training protocol.
* Acute or chronic bone/joint/muscular abnormalities compromising their ability to exercise.
* Neurological conditions that affect balance and, or muscle strength.
* Dementia, altered mental status or any psychiatric condition prohibiting the understanding or rendering of informed consent.