Clinical trial · Interventional
Postoperative Bowel Function After SPS by Different Reconstruction Methods
A Randomized Study From Single Institutions on Postoperative Bowel Function Following Sphincter Preservation Surgery in Patients With Rectal Cancer by Different Reconstruction Methods
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer is one of the most common malignant tumors in the world. Surgery is still the main treatment for rectal cancer. With the popularization of stapler technology and the application of preoperative neoadjuvant therapy, more and more patients with rectal cancer have treated sphincter preservation surgery for rectal cancer. postoperative observation found that some patients with rectal cancer anus-preserving surgery had different degrees of defecation dysfunction after surgery, such as incontinence, tightness, increased frequency of bowel movements, and constipation. These clinical symptoms have been classified as "Low anterior resection syndrome (LARS)" in recent years.Now there is no treatment for LARS.Meanwhile,J-pouch and side-to-end anastomosis can help the patients,but there is few trials can prove this.This trial means to prove weather side-to-end anastomosis can improve bowel of rectal patients afer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bowel; Functional Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| different reconstruction methods | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- end-to-side anastomosis
- description
- All surgeries during the study were performed by the same experienced surgical team and were performed following TME principles. End-to-side anastomosis was used to perform colorectal anastomosis after primary tumor resection.
- interventionNames
- Procedure: different reconstruction methods
- type
- NO_INTERVENTION
- label
- end-to-end anastomosis
- description
- All surgeries during the study were performed by the same experienced surgical team and were performed following TME principles. After resection of the primary tumor, end-to-end anastomosis was used for colorectal anastomosis.
Primary outcomes (1)
- measure
- Postoperative bowel function of 1 year after surgery
- timeFrame
- 1 year after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * The rectal adenocarcinoma is proved by pathology before surgery * The lower margin of the tumor is less than 12cm higher from the anal verge under no anesthesia measured * The tumor can be excised discussed by MDT * Anus preserving operation can be performed * ECOG score ranges between 0 and 2 * The estimate life is supposed to be more than 12 months * The informed consent should be signed Exclusion Criteria: * The patient can not follow the experimental scheme * The case is an emergency * The patient is in pregnant or breast-feeding * TME surgery can not be performed * One-stage anastomosis can not be performed * The patient has a history of anus surgery or rectal surgery * The patient has a history of left hemicolectomy * The patient has a long history of bowel dysfunction，such as diarrhea or dysporia before surgery * The patient has cognitive disorder or communication disorder * The patient has repeat infection or other disorders poorly controlled * The patient joins other clinical trail that may disturb the bowel function
References
Publications (0)
Data not yet available