Clinical trial · Observational
Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos
NCT03668418CI-TRIAL-00034824xenoZunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study consists in a co-clinical trial by using zebrafish embryos. Specifically, an observational prospective clinical trial on patients operated of epato-biliar-pancreatic cancers and gastro-intestinal cancers undergoing a chemotherapy treatment will be run concurrently to an animal trial on zebrafish embryos xenotransplanted with patient cancer cells in order to demonstrate that zebrafish model is able to predict the therapeutic regimen with the best efficacy for each patient.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Biliary Tract Cancer | Malignant Biliary Tract Neoplasm | ALIAS | 0.90 |
| Colo-rectal Cancer | — | UNRESOLVED | — |
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Gall Bladder Cancer | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cisplatin | Drug | Cisplatin | ALIAS |
| Docetaxel | Drug | Docetaxel | ALIAS |
| Epirubicin | Drug | Epirubicin | ALIAS |
| Fluorouracil | Drug | Fluorouracil | ALIAS |
| Gemcitabine | Drug | Gemcitabine | ALIAS |
| Irinotecan | Drug | Irinotecan | ALIAS |
| Lederfolin | Drug | Immunomodulatory Oligonucleotide | ALIAS |
| Nab paclitaxel | Drug | Nab-paclitaxel | ALIAS |
Design
Arms and outcomes
Arms (4)
- label
- Colorectal cancer
- description
- Patients operated for colorectal cancer with or without liver metastasis undergoing a chemotherapy treatment after surgery
- interventionNames
- Drug: Fluorouracil
- Drug: Lederfolin
- Drug: Oxaliplatin
- Drug: Irinotecan
- label
- Esophagus/gastric cancer
- description
- Patients operated for esophagus/gastric cancer undergoing a chemotherapy treatment after surgery
- interventionNames
- Drug: Fluorouracil
- Drug: Lederfolin
- Drug: Oxaliplatin
- Drug: Irinotecan
- Drug: Docetaxel
- Drug: Cisplatin
- Drug: Epirubicin
- label
- Biliary duct cancer
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: \- patients operated of epato-biliar-pancreatic cancers and gastro-intestinal cancers (stage III and IV) undergoing a chemotherapy treatment Exclusion Criteria: * age below 18 years * significant co-morbid cardiovascular and respiratory disease * early stage of disease, (iv) history of prior cancer or prior treatment with any chemotherapy regimen * pregnant and lactating females * patients requiring urgent/ emergency interventions * life expectancy \< 12 weeks
References
Publications (2)
- DERIVEDUsai A, Di Franco G, Piccardi M, Cateni P, Pollina LE, Vivaldi C, Vasile E, Funel N, Palmeri M, Dente L, Falcone A, Giunchi D, Massolo A, Raffa V, Morelli L. Zebrafish Patient-Derived Xenografts Identify Chemo-Response in Pancreatic Ductal Adenocarcinoma Patients. Cancers (Basel). 2021 Aug 17;13(16):4131. doi: 10.3390/cancers13164131. PMID 34439284
- DERIVEDUsai A, Di Franco G, Colucci P, Pollina LE, Vasile E, Funel N, Palmeri M, Dente L, Falcone A, Morelli L, Raffa V. A Model of a Zebrafish Avatar for Co-Clinical Trials. Cancers (Basel). 2020 Mar 13;12(3):677. doi: 10.3390/cancers12030677. PMID 32183229