Clinical trial · Observational
The Relationship Between Postoperative Changes of Oral and Intestinal Flora and Prognosis
Postoperative Oral and Intestinal Flora Changes in Patients With Colorectal Cancer and the Relationship Between These Changes and Prognosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Specific oral microbiome has been found to contribute to the development of colorectal cancer. We speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of oral microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gut Microbiota | — | UNRESOLVED | — |
| Oral Microbiota | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Relapse
- description
- Patients who suffered colorectal cancer or adenoma relapse after curative surgery
- label
- Remission
- description
- Patients who get remission after curative surgery
Primary outcomes (1)
- measure
- Colorectal cancer or adenoma recurred
- timeFrame
- 12 months after surgery
- description
- Use colonoscopy to check for recurrence of colorectal cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Requirements of informed consent and assent of participant, parent or legal guardian as applicable * Patients who underwent exhaustive colorectal cancer surgical resection and accept colonoscopy * Patients between the age of 35 and 75 years old without considering sex * Patients with BMI= 18.5-23.9 * Participants can follow the visit plan Exclusion Criteria: * Patients with colorectal cancer with distant metastasis * Chronic renal diseases and hepatic cirrhosis * Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months * Individuals with a history of Chronic diarrhea * Individuals with a history of Diabetes mellitus * Individuals with a history of Hypertension * Individuals with a history of autoimmune diseases * Use of antibiotics and probiotics 3 mouth before samples collection * Individuals with a history of abdominal operation due to any reason * Individuals with any history of cancer other than colorectal cancer * Individuals with Inflammatory bowel disease
References
Publications (0)
Data not yet available