Clinical Study of a Personalized Neoantigen Cancer Vaccine in Treating Patients With Advanced Malignant Tumor

Inclusion Criteria:

* Must freely sign informed consent;
* Aged 18 to 75 years old;
* The expected survival period is more than 6 months;
* ECOG score is 0 or 1;
* Patients with advanced tumors who fail to receive standard therapy, and those who are not suitable or refuse standard adjuvant therapy;
* Advanced malignant cancer diagnosed by pathology and imageology;
* At least one measurable lesions;
* To be able to obtain sufficient tumor tissue samples and blood samples for analysis, or to have genomic/exon/transcriptional data of tumor tissues and normal tissues, and the data meet the analysis requirements;
* The main organs function is normal, such as the heart, liver and kidney;
* Haematological index:

neutrophil count≥1.5×109/L

hemoglobin≥10g/dL

platelet count≥100×109/L

* Biochemical index:

Total bilirubin is less than or equal to 1.5 times the upper limit of normal value (ULN)

AST and ALT is less than or equal to 2.5 times the upper limit of normal value

Serum creatinine and urea nitrogen (BUN) is less than or equal to 1.5 times the upper limit of normal value

* Pregnant, lactating women and women of child-bearing age must have a negative pregnancy test within 7 days before entering the group, and short-term have no fertility plan, and are willing to take protective measures (contraception or other birth control methods) before and during the clinical trial;
* Good compliance, able to follow research protocols and follow-up procedures.

Exclusion Criteria:

* Diagnosed as other malignant tumor, but cured basal cell carcinoma, thyroid carcinoma, cervical dysplasia etc is excluded;
* No neoantigen was found in the sequencing data;
* There have been bone marrow or stem cell transplants;
* Systemic cancer treatment or other drugs under study were treated within 4 weeks prior to individualized tumor targeted polypeptides treatment;
* Received other polypeptide inoculation 4 weeks before treatment; Patients may not be vaccinated with other polypeptides 8 weeks after the last individualized tumor targeted polypeptides trentment;
* Active bacterial or fungal infections identified clinically (\>= level 2 of NCI-CTC edition 3);
* Patients with HIV, HCV, HBV infection, severe asthma, autoimmune disease, immunodeficiency or treated with immunosuppressive drugs;
* People infected with herpes virus (scabbed for more than 4 weeks is excluded);
* People infected with respiratory virus (cured for more than 4 weeks is excluded);
* Severe coronary or cerebrovascular disease, or other diseases that the investigators considered should to be exclusion;
* Drug abuse, Clinical, psychological or social factor result in affecting informed consent or research implementation;
* Have a history of drug or polypeptide allergies, or people who are allergic to other potential immunotherapies.