Clinical trial · Interventional
Lidocaine Infusion or Quadratus Lumborum Block and Intrathecal Morphine, Versus Intrathecal Morphine Alone
Systemic Lidocaine Infusion or Quadratus Lumborum Block (in Addition to Intrathecal Morphine) Versus Intrathecal Morphine Alone as Part of a Gynecology-Oncology Surgery Early Recovery Protocol
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Recruitment challenges due to COVID-19
Summary
Brief summary (as posted)
This study may provide evidence for whether or not systemic lidocaine infusion offers significant advantage over truncal regional blocks in gynecology oncology surgery patients in terms of post-operative analgesia, recovery, and safety profile. Further, it may show whether there is any increased efficacy of adding truncal regional block or systemic lidocaine versus intrathecal opioid administration alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gynecologic Cancer | Malignant Female Reproductive System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine Bolus Infusion | Drug | — | UNRESOLVED |
| QL block | Procedure | — | UNRESOLVED |
| Saline Bolus Infusion | Drug | — | UNRESOLVED |
| Simulated QL block | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Lidocaine Bolus Infusion
- description
- Patients will also undergo a loading dose of lidocaine, followed by continuous lidocaine infusion in the lidocaine group. Patients will undergo an injection of intrathecal opioid medication (morphine) preoperatively. Patients will undergo a simulated QL block.
- interventionNames
- Drug: Lidocaine Bolus Infusion
- Drug: Saline Bolus Infusion
- Procedure: Simulated QL block
- type
- ACTIVE_COMPARATOR
- label
- QL Block & Saline Bolus Infusion
- description
- Patients will undergo a posterior QL block. Patients will undergo an injection of intrathecal opioid medication (morphine) preoperatively. Patients will receive a saline bolus infusion.
- interventionNames
- Procedure: QL block
- type
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients undergoing gynecologic-oncology surgery involving a mid-line laparotomy incision and as part of the local ERP, who are initially identified as an outpatient * 18 years of age or older Exclusion Criteria: * Pregnancy, * BMI\>45, * Age \>70, * Actual weight \<65 kg * Severe COPD * Severe asthma * Other severe respiratory disease (ILD, etc.) * Local anesthetic allergy * History of cardiac arrhythmia or heart block * CHF * Use of oral anti-arrhythmia agents or lidocaine analogues (i.e. mexiletine) * Inability to be a candidate for intrathecal opioid injection based on medical history and provider judgement
References
Publications (0)
Data not yet available