Clinical trial · Interventional
Measurement of the Skin Sympathetic Nerve Activity
Recording Sympathetic Nerve Activity From the Skin During Surgery Under General Anesthesia : a Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Sympathetic nerve activity can be measured transcutaneously in awake patients by computer-based filtering of raw signal obtained via skin leads attached on the chest. Electrocardiogram can be removed by applying a high-pass filter setting of 150 Hz. Electromyogram can be filtered by applying a high-pass filter setting of 500 Hz or a band-pass filter setting of 500-1000 Hz. However, it is not known whether the skin sympathetic nerve activity (SKNA) can be measured in anesthetized and/or paralyzed patients. Therefore, we planned this pilot study to observe whether the SKNA can be obtained in these patients. If the SKNA ca be observed, it will be presented in milivolt (uV).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Rocuronium | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- ROC
- description
- Neuromuscular blockade is performed in the ROC group by administering rocuronium 0.4\~0.8mg/kg before the insertion of laryngeal airway.
- interventionNames
- Drug: Rocuronium
- type
- NO_INTERVENTION
- label
- Control
- description
- Neuromuscular blockade is not performed.
Primary outcomes (1)
- measure
- The skin sympathetic nerve activity presented as uV obtained via skin leads.
- timeFrame
- During surgery/anesthesia
- description
- A few studies reported that skin sympathetic nerve activity (SKNA) signal could be potentially observed by applying a high-pass filter of 500 Hz or a band-pass filter of 500\~1000 Hz to electric signal from skin leads attached on the skin of the chest in awake volunteers. However, it is not known if it would be also possible to observe the SKNA signal in anesthetized patients. Also, there is no established method for quantitative or qualitative assessment of the SKNA signal.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * patients scheduled to undergo resection of breast cancer under general anesthesia after insertion of laryngeal mask airway Exclusion Criteria: * Autonomic nervous system disease * Medication acting on the autonomic nervous system * Refuse to participate
References
Publications (0)
Data not yet available