Clinical trial · Interventional
Radiation Therapy Planning by Multi-parametric PET/MRI Imaging in Patients With Cervical Cancer
NCT03655977CI-TRIAL-00034685RaPiCCaunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main goal of this project is to evaluate the potential and feasibility of hybrid PET/MRI functional imaging to non-invasively measure tumor characteristics for radiation therapy planning (RT) for cervical cancer. It will be assessed how the complementary information of tumor characteristics can contributed to better understanding of tumor delineation. Another endpoint of this study is to evaluate a new PET-tracer (68Ga-NODAGA- E\[c(RGDyK)\]2) enabling imaging of tumor-angiogenesis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 68Ga-NODAGA-E[c(RGDyK)]2 | Drug | — | UNRESOLVED |
| PET/MRI scan instead of only MRI | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cervical cancer patients
- description
- This pilot study includes 25 women with histologically proven advanced stage primary cervical cancer (FIGO stages ≥IB2-IVA), planned for treatment with radio-chemotherapy.
- interventionNames
- Drug: 68Ga-NODAGA-E[c(RGDyK)]2
- Device: PET/MRI scan instead of only MRI
Primary outcomes (2)
- measure
- Feasibility of PET/MRI in radiation treatment planning workflow
- timeFrame
- 1 year
- description
- Assess the feasibility of PET/MRI in the radiation treatment planning workflow with respect to the adequacy of tumor delineation and planning target volume using PET/MRI data as compared to MRI-only planning.
- measure
- Measure of angiogenesis with 68Ga-NODAGA-E[c(RGDyK)]2 radio-tracer in patient with cervical cancer
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with cervical cancer stage * Tumor \> 1cm * Referred for EBRT and BT planning * Age \> 18 years * Informed consent Exclusion Criteria: * Prior RT of the pelvic region * Pregnancy and lactation * Claustrophobia * MR-incompatible implants
References
Publications (0)
Data not yet available
No reference posted for this study.