Clinical trial · Interventional
High Intensity Interval Training (HIIT) for Patients With Cancer-related Lymphedema in the Lower Limbs
High Intensity Interval Training (HIIT) on Stationary Bike With and Without Compression Stockings for Patients With Cancer-related Lymphedema in the Lower Limbs - a Feasibility Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study is to explore the feasibility and safety of High Intensity Interval Training on a stationary bike for patients with lymphedema in the lower limbs and the role of compression garments during exercise. The design of the study is a cross-over randomized clinical trial. Participants will be randomized into two groups. Both will perform two separate exercise sessions.Group A will perform the first exercise with compression garment and the second session without compression garment, with wash-out period of 1 week between sessions. Group B will perform the exercise sessions in the opposite order.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Endometrial | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
| Cancer of Cervix | Malignant Cervical Neoplasm | ALIAS | 0.90 |
| Cancer of the Prostate | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Cancer, Ovarian | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Lymphedema of Leg | — | UNRESOLVED | — |
| Malignant Melanoma | Melanoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| First exercise session + compression | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- HIIT + compression
- description
- 2 sessions of High Intensity Interval Training (HIIT) on a stationary bike. First exercise session with compression garments/second without.
- interventionNames
- Other: First exercise session + compression
- type
- OTHER
- label
- HIIT - compression
- description
- 2 sessions of High Intensity Interval Training (HIIT) on a stationary bike. First exercise session without compression garments/second with
- interventionNames
- Other: First exercise session - compression
Primary outcomes (2)
- measure
- Feasibility rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * unilateral or bilateral lymphedema in the lower limbs * secondary lymphedema * wears custommade compression stockings during daytime * lymphedema in stage 1, 2A or 2B (Classification from the International Society of Lymphology) * legally competent persons with ability to read and understand Danish. Exclusion Criteria: * inability to perform the intervention, as assessed by the person performing inclusion. * lymphedema in stage 0 or 3 (Classification from the International Society of Lymphology) * ongoing complete decongestive lymphedema therapy * untreated erysipelas * ongoing oncologic treatment: chemotherapy, radiation, immune therapy, * known metastatic cancer * comorbidities e.g. deep venenous thrombosis, serious heart disease, renal insufficiency
References
Publications (1)
- DERIVEDWittenkamp MC, Juhl CB, Zerahn B, Vinther A. Exercise and cancer-related lymphedema in the lower limbs-a randomized cross-over trial on high-intensity interval training (HIIT) with and without compression garments. Support Care Cancer. 2025 Apr 16;33(5):391. doi: 10.1007/s00520-025-09458-x. PMID 40240614