Clinical trial · Interventional
Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma
Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Anatomical liver resection was widely accepted as first line curative therapy for hepatocellular carcinoma. However, number of retrospective clinical studies showed no priority of anatomical resection for hepatocellular, compared with non-anatomical resection. Surgical resection margin is a essential factor that may affect tumor prognosis. It is controversial whether adequate liver resection margin is associated with improved survival outcome in patients with hepatocellular. There was few prospective clinical trial to investigate whether anatomical liver resection is superior to non-anatomical resection or liver resection with adequate margin is superior to that with inadequate margin. This prospective clinical trial aims at fix these issues.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma by BCLC Stage | Hepatocellular Carcinoma by BCLC Stage | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| anatomical liver resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- anatomical liver resection
- description
- resect the tumor located liver segment or lobe
- interventionNames
- Procedure: anatomical liver resection
- type
- EXPERIMENTAL
- label
- resection margin based liver resection
- description
- non-anatomical liver resection, but insure adequate resection margin
- interventionNames
- Procedure: anatomical liver resection
Primary outcomes (1)
- measure
- prognosis
- timeFrame
- 5 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 17 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients diagnosed with hepatocellular carcinoma of BCLC stage A * liver function Child-pugh A * normal indocyanine green retention rate * adequate liver remnant Exclusion Criteria: * age less than 17 y or older than 65 y * unresectable liver cancer * intraoperative ablation * contraindication for liver resection * preoperative treatment for hepatocellular * active hepatitis * pregnant * multi-original tumors * mixed liver cancer (hepatocellular carcinoma and cholangiocellular carcinoma) * tumor recurrence
References
Publications (0)
Data not yet available