Clinical trial · Observational
Minimally Invasive Right Colectomy Anastomosis Study
A Prospective Observational Multi-center 4 Cohort Study Comparing Robotic Assisted and Laparoscopic Invasive Right Colectomy and Intracorporeal Anastomosis Versus Extracorporeal Anastomosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Right colectomy (hemicolectomy) involves the removal of the cecum, the ascending colon, the hepatic flexure, the first one-third of the transverse colon, part of the terminal ileum, and the associated regional fat and lymph nodes, and is the accepted treatment for malignant neoplasms of the right colon. A minimally invasive approach is commonly used for right colectomy, with studies reporting reduced complications, less blood loss, and hospital stay when compared to an open approach. However, there remains controversy regarding whether robotic assistance is advantageous for this technique and whether an intracorporeal (ICA) or extracorporeal anastomosis (ECA) is best. MIRCAST is a prospective, observational, international, multi-center, 4-parallel-cohorts study. Sites or surgeons will select a cohort of the study for which they are qualified. Four cohorts will be the subject of study: 1. Robotic Right Colectomy with ICA 2. Robotic Right Colectomy with ECA 3. Laparoscopic Right Colectomy with ICA 4. Laparoscopic Right Colectomy with ECA All patient assessments will be done according to the sites standard of care. Parameters routinely recorded during right colectomy surgery will be collected prospectively. Enrolled subjects will undergo assessments at the following intervals: pre-operative, operative, discharge, 30 days, 3 months, 1 year and 2 years post-surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Complication | — | UNRESOLVED | — |
| Colectomy | — | UNRESOLVED | — |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extracorporeal Anastomosis | Procedure | — | UNRESOLVED |
| Intracorporeal Anastomosis | Procedure | — | UNRESOLVED |
| Laparoscopic Surgery | Procedure | — | UNRESOLVED |
| Robotic Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Robotic Right Colectomy with ICA
- description
- Robot-assisted surgery (RAS), allows many types of complex MIS procedures using robotic systems to aid in surgical procedures providing more precision, flexibility and control than is possible with other MIS techniques. Intracorporeal anastomosis: when the anastomosis is performed inside the abdominal cavity with a laparoscopic or robotic technique. A Pfannenstiel incision will be done exclusively for specimen extraction.
- interventionNames
- Procedure: Intracorporeal Anastomosis
- Procedure: Robotic Surgery
- label
- Robotic Right Colectomy with ECA
- description
- Robot-assisted surgery (RAS), allows many types of complex MIS procedures using robotic systems to aid in surgical procedures providing more precision, flexibility and control than is possible with other MIS techniques. Extracorporeal anastomosis: when the anastomosis is performed by pulling out the bowel through a laparotomy wherever that laparotomy is performed.
- interventionNames
- Procedure: Extracorporeal Anastomosis
- Procedure: Robotic Surgery
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years or older. * Right colon tumor with indication for right colectomy (benign or malignant disease) * Patient has a life expectancy of at least 12 weeks * Patients with adequate performance status (Eastern Cooperative Oncology Group Scale score of ≤2) * Patient has signed and dated the Informed consent before patient inclusion in the study Exclusion Criteria: * Patient with a comorbid illness or condition that would preclude the use of surgery * Patients with cT4b tumors * Patients unwilling to comply with all follow-up study requirements * Patient undergoing emergency procedures * Planned colonic surgery along with major concomitant procedures (e.g. liver resections, other intestinal resections) * Metastatic disease * Pregnant or suspected pregnancy * Inflammatory Bowel Disease (Crohn´s Disease or Ulcerative Colitis)
References
Publications (1)
- DERIVEDGomez Ruiz M, Bianchi PP, Chaudhri S, Gerjy R, Gogenur I, Jayne D, Khan JS, Rautio T, Sanchez-Guillen L, Spinoglio G, Ulrich A, Rouanet P. Minimally invasive right colectomy anastomosis study (MIRCAST): protocol for an observational cohort study of surgical complications using four surgical techniques for anastomosis in patients with a right colon tumor. BMC Surg. 2020 Jul 13;20(1):151. doi: 10.1186/s12893-020-00803-x. PMID 32660467