Stereotactic Radiotherapy (SBRT) in Patients With Locally Advanced Pancreatic Cancer (LAPC)

Inclusion Criteria:

* LAPC (Karolinska Type B, C or D1)
* Cytologically or histologically verified adenocarcinoma/carcinoma
* Prior combination chemotherapy for 2-6 months (unless contraindicated) and no sign of progressive disease
* The patient is medically operable (i.e. no co-morbidity which can preclude anaesthesia or surgery)
* World Health Organization performance status 0-1
* Age ≥ 18 years
* Adequate hepatic function: bilirubin \<3.0 x Upper Normal Limit, International Normalized Ratio \<1.6, Activated Partial Thromboplastin Time \< 1,5 x Upper Normal Limit. Patients with obstruction of bile duct or gut must be drained before start of therapy
* Oral and written informed consent must be obtained prior to registration with planned date of first treatment within 14 days from registration.

Exclusion Criteria:

* M1 disease
* Prior radiotherapy to abdominal cavity
* Pregnancy or breast-feeding. Fertile patients must use adequate contraceptives
* Severe uncontrolled concomitant illness (e.g. clinically significant cardiac disease or myocardial infarction within 12 months)