Clinical trial · Interventional
Sequence of Vessel Interruption and Circulating Tumor Cells in Surgical Lung Cancer
Impact of the Sequence of Vessel Interruption During Major Pulmonary Resections for Non-small Cell Lung Cancer Based on Circulating Tumor Cells Detection Peroperatively in the Tumor-draining Pulmonary Vein: a Randomized Pilot Study.
NCT03645252CI-TRIAL-00034555CTC-01unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to define the impact of the sequence of vessel interruption on change in CTC and CTC clusters density in the tumor-draining pulmonary vein between the period before surgical manipulation and before tumor-draining vein interruption.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Circulating Tumor Cell | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Arteries interruption before vein interruption | Procedure | — | UNRESOLVED |
| Vein interruption before any other surgical manipulation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Vein first
- description
- Tumor-draining pulmonary vein is interrupted first and before any surgical manipulation.
- interventionNames
- Procedure: Vein interruption before any other surgical manipulation
- type
- ACTIVE_COMPARATOR
- label
- Arteries before vein
- description
- Lobar arteries (+/- bronchus and inter-lobar fissures) are interrupted before tumor-draining pulmonary vein.
- interventionNames
- Procedure: Arteries interruption before vein interruption
Primary outcomes (2)
- measure
- Changes in CTC density
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * NSCLC with preoperative pathological evidence, * Pure solid nodule or part-solid (\>50%) ground glass nodule on CT scan * Clinical stage tumor-1 to 3, clinical stage node-0, clinical stage metastasis-0, (except clinical stage tumor-3 for chest wall, pericardium or phrenic nerve invasion) * Video-assisted thoracoscopic lobectomy or bi-lobectomy Exclusion Criteria: * Pneumonectomy, segmentectomy, non anatomic resection * History of thoracic surgery on the same side * Necessity to perform a non-anatomic resection in addition to the lobectomy * No preoperative histological diagnosis * Pure ground glass nodule on CT scan * Clinical stage tumor-4 or 3 for chest wall, pericardium or phrenic nerve invasion * Clinical stage node ≥1 * Neoadjuvant therapy * Second cancer or cancer in the past 5 years * First approach through thoracotomy with ribs spreading * Pregnancy, \<18 years of age * Pulmonary adherences/symphysis found during surgery (impossible to perform the first blood sample without lung manipulation)
References
Publications (2)
- RESULTCrosbie PA, Shah R, Krysiak P, Zhou C, Morris K, Tugwood J, Booton R, Blackhall F, Dive C. Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC. J Thorac Oncol. 2016 Oct;11(10):1793-7. doi: 10.1016/j.jtho.2016.06.017. Epub 2016 Jul 25. PMID 27468936
- RESULTHashimoto M, Tanaka F, Yoneda K, Takuwa T, Matsumoto S, Okumura Y, Kondo N, Tsubota N, Tsujimura T, Tabata C, Nakano T, Hasegawa S. Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):775-83. doi: 10.1093/icvts/ivu048. Epub 2014 Mar 11. PMID 24618055