Clinical trial · Interventional
Epidural Analgesia and Postoperative Respiratory Functions (EPAPRES)
Comparison of Thoracic Epidural and Intravenous Analgesia From the Perspective of Recovery of Respiratory Function at Early Post-thoracotomy Period in Lung Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients operated with posterolateral thoracotomy were enrolled. Post-operative analgesia was provided either by TEA with 0.1% bupivacaine or pethidine based intravenous analgesia (IVA) in our sample population. Perception of pain was quantified by Visual Analogue Scale (VAS) at rest and during coughing. Arterial blood samples were collected at 1st, 24th and 72nd hours of post-operative period. Pre-operative and post-operative 72nd-hour spirometric measurements were recorded
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Respiration Disorders | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bupivacaine | Drug | — | UNRESOLVED |
| Thoracic epidural analgesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Thoracic Epidural Analgesia
- description
- Population to whom thoracic epidural analgesia with bupivacaine as a component of multimodal analgesia was administered.
- interventionNames
- Procedure: Thoracic epidural analgesia
- Drug: Bupivacaine
- type
- ACTIVE_COMPARATOR
- label
- Intravenous analgesia
- description
- Population to whom combined intravenous analgesia was administered.
- interventionNames
- Procedure: Thoracic epidural analgesia
Primary outcomes (1)
- measure
- Postoperative FEV1 and FVC alterations
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists -ASA- Class I to III) * Scheduled for an elective thoracic surgical procedure with posterolateral thoracotomy Exclusion Criteria: * Individuals beyond defined age limits * Having psychiatric problems * Having an auditory deficit * Active drug abuse * Severe cardiovascular system disorders * Severe respiratory depression depicted as having less than 50% of the predicted value of forced expiratory volume * Refusing to give consent * Contraindication to insertion of an epidural catheter.
References
Publications (3)
- RESULTErturk E, Aydogdu Kaya F, Kutanis D, Besir A, Akdogan A, Geze S, Tugcugil E. The effectiveness of preemptive thoracic epidural analgesia in thoracic surgery. Biomed Res Int. 2014;2014:673682. doi: 10.1155/2014/673682. Epub 2014 Mar 13. PMID 24745020
- RESULTHelander EM, Webb MP, Bias M, Whang EE, Kaye AD, Urman RD. Use of Regional Anesthesia Techniques: Analysis of Institutional Enhanced Recovery After Surgery Protocols for Colorectal Surgery. J Laparoendosc Adv Surg Tech A. 2017 Sep;27(9):898-902. doi: 10.1089/lap.2017.0339. Epub 2017 Jul 25. PMID 28742434
- RESULTRawal N. Epidural technique for postoperative pain: gold standard no more? Reg Anesth Pain Med. 2012 May-Jun;37(3):310-7. doi: 10.1097/AAP.0b013e31825735c6. PMID 22531384