Clinical trial · Observational
Disseminated Tumour Cells (DTC) in Left Sided Colorectal Cancer (LSCC).
Prognostic Value of Disseminated Tumour Cells in Bone Marrow in Patients With Left-sided Colorectal Cancer.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Two metaanalyses of studies on the prognostic significance of circulating cancer cells in colorectal cancer indicated, that the presence of circulating tumour cells (CTC) in the peripheral blood is the negative prognostic factor. However there is no sufficient evidence that disseminated tumour cells (DTC) in the bone marrow of the colorectal cancer patients influence the prognosis. There is the evidence that right-sided and left- sided cancers may have different biology and different prognosis. Therefore in this study the investigators concentrated on the left colon and rectum locations with the locally advanced cancer being the main area of interest. The aim of this study was to analyse the relation of DTC with the tumor characteristics, cancer progression and survival in left sided colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Marrow Tumor Cell Infiltration | Colorectal Neoplasm | PROBABILISTIC | 0.70 |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bone marrow analysis to identify disseminated tumour cells | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Bone Marrow DTC
- description
- Patients with left-sided colorectal cancer and disseminated tumour cells in the bone marrow
- interventionNames
- Diagnostic Test: Bone marrow analysis to identify disseminated tumour cells
- label
- No bone marrow DTC
- description
- Patients with left-sided colorectal cancer and no disseminated tumour cells in the bone marrow
- interventionNames
- Diagnostic Test: Bone marrow analysis to identify disseminated tumour cells
Primary outcomes (1)
- measure
- Overall survival (OS)
- timeFrame
- 5 years
- description
- OS in patients with and without DTC in bone marrow
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age \> 18 years * histologically proven left-sided colorectal cancer * signed informed consent Exclusion Criteria: * synchronous right sided colon cancer * history of other neoplasm * inability to understand and sign informed consent
References
Publications (0)
Data not yet available