Clinical trial · Interventional
The PRISM Intervention for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation
The Promoting Resilience in Stress Management (PRISM) Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation
NCT03640325CI-TRIAL-00081936completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Multisite Randomized Controlled Trial (RCT) testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults receiving hematopoietic cell transplantation for hematology malignancy.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adherence, Medication | — | UNRESOLVED | — |
| Adolescent Behavior | — | UNRESOLVED | — |
| Anxiety | — | UNRESOLVED | — |
| Bone Marrow Neoplasms | Bone Marrow Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Coping Skills | — | UNRESOLVED | — |
| Depression | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PRISM (Promoting Resilience in Stress Management) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- PRISM (Promoting Resilience in Stress Management)
- description
- Resilience Skills Training
- interventionNames
- Behavioral: PRISM (Promoting Resilience in Stress Management)
- type
- NO_INTERVENTION
- label
- Usual Care
- description
- Usual psychosocial care (control arm, no intervention)
- type
- NO_INTERVENTION
- label
- Caregivers
- description
- Caregivers of participants, no intervention
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 24 Years
Show eligibility criteria text
Inclusion Criteria for adolescent/young adult (AYA) patient: * Patient aged 12-24 years * Receiving hematopoietic cell transplantation (HCT) for malignancy or cancer predisposition syndrome * Within 4 weeks of HCT "day zero" * Able to speak English * Able to read English or Spanish * Cognitively able to participate in interviews Exclusion Criteria for AYA patient: * Patient refusal * Cognitively or physically unable to participate in interviews * Unable to speak English * Unable to read English or Spanish For enrolled caregivers of AYA patient (no age limit): Inclusion criteria: * AYA Child of caregiver agreed to participate * One caregiver per patient-caregiver dyad * Parent/guardian cognitively and physically able to participate * Parent/guardian is able to speak/read English or Spanish
References
Publications (2)
- DERIVEDTaylor MR, Cole SW, Bradford MC, Zhou C, Fladeboe KM, Knight JM, Baker KS, Yi-Frazier JP, Rosenberg AR. Resilience Intervention Improves Stress-Related Gene Expression in Adolescent and Young Adult HCT Recipients. Transplant Cell Ther. 2024 Dec;30(12):1209.e1-1209.e7. doi: 10.1016/j.jtct.2024.09.014. Epub 2024 Sep 19. PMID 39303988
- DERIVEDFladeboe KM, Scott S, Comiskey L, Zhou C, Yi-Frazier JP, Rosenberg AR. The Promoting Resilience in Stress Management (PRISM) intervention for adolescents and young adults receiving hematopoietic cell transplantation: a randomized controlled trial protocol. BMC Palliat Care. 2022 May 19;21(1):82. doi: 10.1186/s12904-022-00966-9. PMID 35585525