Clinical trial · Observational
CPET and Outcome After Oesophagogastric Cancer Surgery
Cardiopulmonary Exercise Variables Are Associated With Postoperative Morbidity and Mortality After Major Oesophagogastric Cancer Surgery - A Multicentre Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Primary Aim: The present study is a retrospective analysis of prospectively collected clinical data. Anonymized data from patients collected during routine clinical care from 9 units in the United Kingdom who undertake upper gastrointestinal (UGI) cancer surgery and perform pre-operative cardiopulmonary exercise testing will be interrogated. Data will be pooled at a central location (University Hospitals Southampton) and used to investigate the relationship between selected cardiopulmonary exercise testing (CPET) variables, in-hospital post-operative and survival outcomes after major UGI cancer surgery. Rationale: Our primary aim is to establish a reliable relationship between post-operative survival (1 and 3 -year) and oxygen uptake (VO2) at peak exercise (VO2 Peak); a secondary aim is to explore the multivariable relationship between selected CPET variables especially VO2 at the estimated lactate threshold/anaerobic threshold (AT), together with other selected CPET derived variables, and other important prognostic variables with post-operative complications (morbidity and mortality) in an attempt to risk stratify patients before major UGI surgery. Trial Design: Multicentre observational Inclusion Criteria: We aim to include all patients aged \>18 years considered eligible by the MDT for major curative UGI cancer surgery and undergoing an enhanced recovery programme after surgery. Patients undergoing neoadjuvant chemotherapy or chemoradiotherapies will also be included. Patients having a CPET and initially scheduled for curative surgery, but end up not having surgery due to disease progression or other clinical reasons will be included and analysed separately. Exclusion Criteria: Patients will be excluded if they are physically unable to perform a CPET on a cycle ergometer, patients having emergency surgery, patients lacking complete in-hospital morbidity or mortality data and patients undergoing preoperative exercise interventions. Primary Trial Endpoints: 3 year overall survival
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Upper Gastrointestinal Disorders | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cardiopulmonary exercise testing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Upper gastrointestinal cancer
- description
- Upper gastrointestinal cancers including oesophagus and stomach
- interventionNames
- Diagnostic Test: Cardiopulmonary exercise testing
Primary outcomes (1)
- measure
- Fitness
- timeFrame
- up to 4 weeks before pre-surgery
- description
- Oxygen uptake at estimated lactate threshold
Secondary outcomes (1)
- measure
- Sarcopenia defined by skeletal muscle radiation attenuation
- timeFrame
- up to 4 weeks before pre-surgery
- description
- Radiation attenuation for skeletal muscle at L3 using Slico-matic software
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * We aim to include all patients aged \>18 years considered eligible by the MDT for major curative UGI cancer surgery * undergoing an enhanced recovery programme after surgery. * Patients undergoing neoadjuvant chemotherapy or chemoradiotherapies will also be included. * Patients having a CPET and initially scheduled for curative surgery, but end up not having surgery due to disease progression or other clinical reasons will be included and analysed separately. Exclusion Criteria: * physically unable to perform a CPET on a cycle ergometer, * patients having emergency surgery, * patients lacking complete in-hospital morbidity or mortality data and patients undergoing preoperative
References
Publications (1)
- DERIVEDWest MA, Rahman S, Jack S, Grocott MPW, Levett DZH; Perioperative Exercise Testing and Training Society (POETTS); Rashid Y, Griffiths J, Ezra M, Ayres L, Neville-Webbe H, Javed MS, Shrotri M, Khan I, Whitmore D, Prabhu P, Timbrell D, Allen S, Packham AO, Sharpe D, Anderson H, Minto G, McAleer S, McPhail S, Alasmar M, Hartley RA, Sultan J, Grace B, Underwood TJ, Byrne J, Noble F, Kelly J, Ansell G, Edwards M. Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery-a multicentre observational study. BJA Open. 2024 Jun 7;10:100289. doi: 10.1016/j.bjao.2024.100289. eCollection 2024 Jun. PMID 38947220