Clinical trial · Observational
Maladaptive Adipose Tissue Activity in Cancer
NCT03621124CI-TRIAL-00107879terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): COVID-19 Pandemic
Summary
Brief summary (as posted)
The purpose of this pilot research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Nos | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Resting Energy Expenditure | Procedure | — | UNRESOLVED |
| Thermal Comfort Questionnaire | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Brown Adipose Tissue Positive patients
- description
- Patients with known malignancy and incidental finding of positron emission tomography/ computerized tomography (PET/CT) scans positive for brown adipose tissue (BAT). After obtaining informed consent and all initial screening visit procedures, patients will participate in two four-hour recording sessions in the whole room indirect calorimeter to assess resting energy expenditure, and patient's thermal (comfort) response to the temperature of the room.
- interventionNames
- Procedure: Resting Energy Expenditure
- Other: Thermal Comfort Questionnaire
- label
- Brown Adipose Tissue Negative Patients
- description
- Patients with known malignancy and no evidence of brown adipose tissue BAT activity positron emission tomography/ computerized tomography (PET/CT) scans to be matched to group 1 for primary tumor and stage, sex, age (±5 years), BMI (±3 Kg/m2). After obtaining informed consent and all initial screening visit procedures, patients will participate in two four-hour recording sessions in the whole room indirect calorimeter to assess resting energy expenditure, and patient's thermal (comfort) response to the temperature of the room.
- interventionNames
- Procedure: Resting Energy Expenditure
- Other: Thermal Comfort Questionnaire
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * ≥ 40 years of age * Have active cancer diagnosis. * Have had a PET/CT scan within the past 12 months at time of enrollment. * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Current use of beta-blockers * Women who are pregnant or unsure of their pregnancy status * Women who are breastfeeding * Suffers from severe claustrophobia * Diagnosed with a serious psychiatric condition which could impede the judgement of the investigators, and/or the successful conduct of the recording. * In remission stage for cancer diagnosis
References
Publications (0)
Data not yet available
No reference posted for this study.