Clinical trial · Interventional
Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery
NCT03619538CI-TRIAL-00115354NEFOPAMcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colonic Neoplasms | Colon Neoplasm | ALIAS | 0.90 |
| Diverticulosis, Colonic | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nefopam | Drug | — | UNRESOLVED |
| saline solution | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- control group
- interventionNames
- Other: saline solution
- type
- EXPERIMENTAL
- label
- Nefopam group
- interventionNames
- Drug: Nefopam
Primary outcomes (1)
- measure
- Estimate morphine consumption
- timeFrame
- over 48 hours
- description
- mg
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patient with a score ASA between I and III * Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis * Patient that signed the consent form Exclusion Criteria: * \- Patient treated in emergency situation * Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis) * Patient that needs a surgery for restoration of continuity * Patient pregnant, breastfeeding, or during periods of genital activity using no contraception. * Patient with contraindications to nefopam, morphine, or paracetamol * Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment * Patient under analgesics treatment * Patient who participated in a clinical study in the previous 6 months.
References
Publications (1)
- RESULTCuvillon P, Zoric L, Demattei C, Alonso S, Casano F, L'hermite J, Ripart J, Lefrant JY, Muller L. Opioid-sparing effect of nefopam in combination with paracetamol after major abdominal surgery: a randomized double-blind study. Minerva Anestesiol. 2017 Sep;83(9):914-920. doi: 10.23736/S0375-9393.17.11508-7. Epub 2017 Feb 13. PMID 28192892