Clinical trial · Observational
Plant-based Diets and Risk of Cancer in the Adventist Health Study-2
Cancer Epidemiology in Seventh-day Adventists
NCT03615599CI-TRIAL-00102037AHS-2active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Breast | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer, Colorectal | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Cancer, Prostate | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Seventh-day Adventists
- description
- This is a prospective cohort study of 96,000 members of the Seventh-day Adventists Church in the United States and Canada age 30 and older at the time of enrollment who are proficient in English language.
Primary outcomes (1)
- measure
- Incident cases of breast cancer among subjects with documented dietary habits.
- timeFrame
- Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
- description
- Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.
Secondary outcomes (1)
- measure
- Incident cases of prostate cancer among subjects with documented dietary intakes.
- timeFrame
- Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Member of a Seventh-day Adventist church \>30 years of age Ability to read English Live in the US or Canada Exclusion Criteria: * Less than 30 years of age * Church members who did not complete the baseline questionnaire. * Incarcerated or institutionalized people * Non-English speakers
References
Publications (2)
- BACKGROUNDButler TL, Fraser GE, Beeson WL, Knutsen SF, Herring RP, Chan J, Sabate J, Montgomery S, Haddad E, Preston-Martin S, Bennett H, Jaceldo-Siegl K. Cohort profile: The Adventist Health Study-2 (AHS-2). Int J Epidemiol. 2008 Apr;37(2):260-5. doi: 10.1093/ije/dym165. Epub 2007 Aug 27. No abstract available. PMID 17726038
- DERIVEDFraser GE, Jacobsen BK, Knutsen SF, Mashchak A, Lloren JI. Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2. Cancer Causes Control. 2020 Apr;31(4):341-351. doi: 10.1007/s10552-020-01279-z. Epub 2020 Feb 25. PMID 32100191