Clinical trial · Interventional
The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy
The Effect of Single High Dose of Vitamin D3 on Short-term Postoperative Pain in Patients Under Craniotomy for Brain Tumor Resection
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Vitamin D is a hormone mainly synthesized in the skin in the presence of sunlight. Like other hormones, vitamin D plays a role in a wide range of processes in the body. Some studies have shown vitamin D has anti-inflammatory effects in the body by reducing the release of pro-inflammatory cytokines and suppressing T-cell responses. Therefore, vitamin D may be effective on reduce pain by such mechanisms. In this trial patients with brain tumor under craniotomy will receive a single high dose vitamin D compared to the control group.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| vitamin D | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Vitamin D
- description
- Intervention patients will be received a single dose of 300000 IU vitamin D via intramuscular injection
- interventionNames
- Drug: vitamin D
- type
- NO_INTERVENTION
- label
- control
- description
- Control patients will not be received any intervention
Primary outcomes (1)
- measure
- Short-term postoperative pain: measured by the visual analogue scale or visual analog scale (VAS) that is a pain rating scale
- timeFrame
- Up to three days after surgery
- description
- By questioning from patients for daily pain intensity based on the VAS scale in which pain intensity score by 0 to 10. The "0" and "10" score indicates "no pain" and "worst pain",respectively. also "1-3" , "4-6" and "7-9" score indicates mild, mild to moderate and severe pain, respectively.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Written informed consent of patient or legal representative * 25(OH)D level below 20ng/dL Exclusion Criteria: * Other trial participation, including previous participation in the pilot trial * Pregnant or lactating women * Hypercalcemia * Hyperphosphatemia * Tuberculosis * Sarcoidosis * History of nephrolithiasis * History of hyperparathyroidism * Medications that interfere with vitamin D metabolism * Renal Insufficiency
References
Publications (0)
Data not yet available