Clinical trial · Interventional
Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening (LCS)
Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial seeks to evaluate the effectiveness of alternative strategies to integrate smoking cessation interventions into the delivery of low-dose CT (LDCT) lung cancer screening. Using a factorial design, current smokers who enroll will be randomly assigned to receive these interventions: (1) smoking cessation counseling support by telephone or videoconferencing (short duration vs. long duration); (2) nicotine patch treatment (NRT) (short vs.long duration); (3) counselor-facilitated referral (vs. no referral) to an online resource to connect smokers to a community-based social service resources.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Smoking, Tobacco | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Community Resource | Behavioral | — | UNRESOLVED |
| Counseling | Behavioral | — | UNRESOLVED |
| Nicotine patch | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (8)
- type
- EXPERIMENTAL
- label
- Short, Short, Present
- description
- 4 weeks of counseling (by phone or videoconferencing) + 2 weeks of nicotine patch + referral to community resource.
- interventionNames
- Behavioral: Counseling
- Drug: Nicotine patch
- Behavioral: Community Resource
- type
- EXPERIMENTAL
- label
- Short, Long, Present
- description
- 4 weeks of counseling (by phone or videoconferencing) + 8 weeks of nicotine patch + referral to community resource.
- interventionNames
- Behavioral: Counseling
- Drug: Nicotine patch
- Behavioral: Community Resource
- type
- EXPERIMENTAL
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Scheduled to undergo LDCT-LCS at a participating Mass General Brigham Health Care System LCS site * Speak English or Spanish. * Current smokers: smoked a cigarette, even a puff, in the last 30 days. * Medicare coverage requirement (age 50-80 years, 20+ pack/years). * Residing within the USA. Exclusion Criteria: * Undergoing lung CT as part of a diagnostic or abnormal follow-up evaluation. * Unable to give informed consent due to psychiatric or cognitive impairment as determined in consultation with study PI or treating clinician. * No access to a telephone or cannot communicate by telephone.
References
Publications (3)
- DERIVEDPark ER, Haas JS, Rigotti NA, Neil JM, Marotta CJ, Wint AJ, Gonzalez I, McGovern SE, Chang Y, Levy DE, Flores EJ, Merker VL, Noonan E, Bliss CC. Integrating Tobacco Treatment Into Lung Cancer Screening: The Screen Assist Factorial Randomized Clinical Trial. JAMA Intern Med. 2025 May 1;185(5):531-539. doi: 10.1001/jamainternmed.2024.8399. PMID 40029643
- DERIVEDAvila JC, Flores EJ, Su YJ, Haas JS, Park ER, Rigotti NA. Association of individual and neighborhood socioeconomic status with outcomes of a smoking cessation intervention provided in the lung cancer screening setting. Prev Med. 2025 Feb;191:108207. doi: 10.1016/j.ypmed.2024.108207. Epub 2024 Dec 16. PMID 39694102
- DERIVEDPark ER, Neil JM, Noonan E, Howard SE, Gonzalez I, Marotta C, Wint AJ, Levy DE, Chang Y, Rigotti NA, Haas JS. Leveraging the Clinical Timepoints in Lung Cancer Screening to Engage Individuals in Tobacco Treatment. JNCI Cancer Spectr. 2022 Nov 1;6(6):pkac073. doi: 10.1093/jncics/pkac073. PMID 36350049