Clinical trial · Observational
Neurocognitive Risks in Children With Solid Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The survival rate of children with cancer has improved significantly in recent years thanks to the progress of different therapies. The neurocognitive sequelae related to treatments and illness are more or less well known. Four factors seem to be associated with neurocognitive sequelae: treatment, the tumor itself, environmental factors like the socio-economic status of parents and biological factors. Main purpose of the study is to establish a score to assess the risk of neurocognitive sequelae in these children based on these factors (treatment, tumor, and environmental factors)
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Solid Tumor in Children | — | UNRESOLVED | — |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| The "BRIEF" | Other | — | UNRESOLVED |
| The Child Executive Function Evaluation Battery CEF | Other | — | UNRESOLVED |
| The "CONNERS 3 long version" | Other | — | UNRESOLVED |
| The Family Functioning Inventory FAD) | Other | — | UNRESOLVED |
| The 'fatigue' version of the PEDS-QL (Tessier et al., 2009: child version for the extra-cerebral tumour cohort) | Other | — | UNRESOLVED |
| The 'fatigue' version of the PEDS-QL (Tessier et al., 2009: parent and child-adolescent version for the brain tumour cohort) | Other | — | UNRESOLVED |
| The NEPSY-II | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Patients treated for a brain tumor
- description
- As part of their usual follow-up, these patients have neuropsychological evaluations following their treatment. A complete neuropsychological evaluation will therefore be performed as part of their usual follow-up during the inclusion period of this study and only the data from this evaluation will be taken into account for the statistical analysis of this study.
- interventionNames
- Other: The WISC-V
- Other: The NEPSY-II
- Other: The Child Executive Function Evaluation Battery CEF
- Other: The "CONNERS 3 long version"
- Other: The "BRIEF"
- Other: The "PEDS-QL quality of life"
- Other: The 'fatigue' version of the PEDS-QL (Tessier et al., 2009: parent and child-adolescent version for the brain tumour cohort)
- Other: The Family Functioning Inventory FAD)
- label
- Patients treated for a non-cerebral tumor
- description
- A single neuropsychological assessment will be proposed to these patients after the end of treatment and during the inclusion period of this study. This evaluation will be carried out during a visit to Gustave Roussy as part of their usual follow-up. If on the occasion of this evaluation, cognitive disorders or psychological disorders were highlighted, a neuropsychological and / or psychological follow-up would be proposed.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patient aged 6 to 16 years and 11 months during the study period * Type of pathology: solid tumor * Place of treatment and follow-up: Gustave Roussy * Minimum time from the end of the initial treatment: * For patients who have not received treatment with methotrexate: 6 months * For patients being treated with methotrexate: none * Obtaining the non-opposition of parents / legal representatives * Affiliation to a social security scheme. Exclusion Criteria: * Patients with other pathologies associated with mental retardation (autism, genetic syndrome ...) * Patients lost to follow-up * Deceased patients * Patients treated for a pathology whose prognosis is involved in the very short term (infiltrating glioma of the brainstem, recurrence of the pathology during treatment) * Non-French speaking patients
References
Publications (0)
Data not yet available