Clinical trial · Interventional
Intensified Follow-up of Lung Cancer Using Weekly Questionnaires Via the Internet
ProWide - Patient Reported Outcomes Used for Weekly Internet-based DEtection of Progressive Disease in Lung Cancer; a Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial (RCT) will test if weekly supplementary internet-based self-monitoring of 12 core symptoms can increase survival in Danish lung cancer patients during follow-up or maintenance treatment. A threshold mechanism will automatically send an alert to the hospital in case of alarming or worsening symptoms and the patient will be contacted by the treating clinicians.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Weekly Internet based PRO questionnaires | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- PRO intervention
- description
- Weekly PRO questionnaires Quality of life every 2 months
- interventionNames
- Other: Weekly Internet based PRO questionnaires
- type
- NO_INTERVENTION
- label
- Standard of care
- description
- Quality of life every 2 months
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 2 years
Secondary outcomes (8)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
1. Patients with lung cancer (NSCLC and SCLC), who have received 1st line induction treatment\* for lung cancer and have no sign of progressive disease at first evaluation CT scan.
2. Patients diagnosed with stage III treated with palliative intention, and stage IV, regardless of treatment intention.
3. Diagnosis proven by cytology or histology
4. Age ≥ 18 years
5. Performance status (PS) ≤ 2 within 15 days before enrolment
6. First evaluation CT scan performed within four weeks from enrolment
7. Patient with acess to internet, Mobile phone and E-boks (Danish digital secure mail system)
8. Patient has given his/her written informed consent before any specific procedure from protocol
* Induction treatment includes:
* Standard doublet chemotherapy
* Immunotherapy
* Targeted therapy
* Palliative radiotherapy
* Local treatment of oligometastatic disease, including surgery and stereotactic radiotherapy
* Any combination of the above-mentioned treatment modalities Patients are eligible regardless of whether they at the time of inclusion continue maintenance treatment or not
Exclusion Criteria:
1. Progressive disease at first evaluation scan
2. Persons deprived of liberty or under guardianship or curators
3. Dementia, mental alteration or psychiatric disease that can compromise informed consent from the patient and / or adherence to the protocol and the monitoring of the trial
4. Pregnant or breastfeeding women
5. Patient participating in another interventional study during the surveillance period. This is only relevant for studies that might interfere with the intervention. Participation in protocols related only to treatment will not preclude participation in the present study. Cases of doubt will be settled by the protocol committee.References
Publications (1)
- DERIVEDFriis RB, Pappot H, Hjollund NH, McCulloch T, Holt MI, Persson GF, Wedervang K, Clausen MM, Wahlstrom S, Hansen KH, Rasmussen TR, Dalton SO, Jakobsen E, Linnet H, Skuladottir H; Danish Lung Cancer Group. Remote Symptom Monitoring of Patients With Advanced Lung Cancer (The ProWide Study): A Randomized Controlled Trial. JCO Oncol Pract. 2025 Jun;21(6):813-823. doi: 10.1200/OP-24-00562. Epub 2024 Dec 10. PMID 39657078