Clinical trial · Interventional
Bioclinical Study of Scalp Photoaging of a Population Male Over 65 Years Old.
Bioclinical Study of Scalp Photoaging of a Population Male Over 65 Years Old. Mono-centric Prospective Study
NCT03603587CI-TRIAL-00043838BACCHUSterminatedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Organisation issues
Summary
Brief summary (as posted)
The aging of skin, especially that of the scalp, is a combination of intrinsic and extrinsic aging factors secondary to the chronic sun exposure. For men with an alopecia genetic (= bald men), the solar part, in skin aging process, is major. The helio-dermal scalp is frequently the site of cancers mainly after 65 years. Objectives are to identify specific biomarkers involved in the photo-aging of the alopecic scalp
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Skin Aging | — | UNRESOLVED | — |
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biopsy | Procedure | — | UNRESOLVED |
| blood sample | Diagnostic Test | — | UNRESOLVED |
| examination of the scalp | Diagnostic Test | — | UNRESOLVED |
| Norwood scale | Diagnostic Test | — | UNRESOLVED |
| questionnaire of clinicals signs | Diagnostic Test | — | UNRESOLVED |
| questionnaire of the history of the hair loss | Diagnostic Test | — | UNRESOLVED |
| questionnaire on sun exposure | Diagnostic Test | — | UNRESOLVED |
| scinexa score | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients who will benefit from the removal of a scalp tumour
- description
- Patients who will benefit from the removal of a scalp tumour in the alopecic zone will be recruited in the dermatology department of the St-Etienne University Hospital. They will have biopsy, blood sample, examination of the scalp, questionnaire on sun exposure, Norwood scale, scinexa score, questionnaire of clinicals signs and questionnaire of the history of the hair loss.
- interventionNames
- Procedure: biopsy
- Diagnostic Test: blood sample
- Diagnostic Test: questionnaire on sun exposure
- Diagnostic Test: examination of the scalp
- Diagnostic Test: Norwood scale
- Diagnostic Test: questionnaire of clinicals signs
- Diagnostic Test: scinexa score
- Diagnostic Test: questionnaire of the history of the hair loss
Primary outcomes (1)
- measure
- Scalp skin biomarkers
- timeFrame
- at the surgery (about 28 days after the inclusion)
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Requiring excision of an alopecic scalp lesion * from consent signed * Patient affiliated or entitled to a social security. Exclusion Criteria: * scalp infection * inflammatory disease of the scalp * genetic disease with even partial expression of the scalp * medical treatment of scalp less than 3 weeks old * antecedent radiotherapy of the cephalic extremity * prior surgery of the scalp with regard to the area sampled * Application of hair implants, or any other surgical or medical procedures of the scalp * Washing of the scalp or application of a cosmetic product for less than 48 hours * Artificial hair coloring. * any contraindication to surgical excision
References
Publications (5)
- BACKGROUNDZouboulis CC, Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 2011 Jan-Feb;29(1):3-14. doi: 10.1016/j.clindermatol.2010.07.001. PMID 21146726
- BACKGROUNDUitto J. Understanding premature skin aging. N Engl J Med. 1997 Nov 13;337(20):1463-5. doi: 10.1056/NEJM199711133372011. No abstract available. PMID 9358147
- BACKGROUNDShin MH, Rhie GE, Park CH, Kim KH, Cho KH, Eun HC, Chung JH. Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin. J Invest Dermatol. 2005 Feb;124(2):315-23. doi: 10.1111/j.0022-202X.2004.23588.x. PMID 15675949
- BACKGROUNDRock K, Grandoch M, Majora M, Krutmann J, Fischer JW. Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling. J Biol Chem. 2011 May 20;286(20):18268-76. doi: 10.1074/jbc.M110.201665. Epub 2011 Mar 17. PMID 21454612
- BACKGROUNDVarani J, Spearman D, Perone P, Fligiel SE, Datta SC, Wang ZQ, Shao Y, Kang S, Fisher GJ, Voorhees JJ. Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am J Pathol. 2001 Mar;158(3):931-42. doi: 10.1016/S0002-9440(10)64040-0. PMID 11238041