Clinical trial · Interventional
PeRioperative Omega Three and the Effect on ImmuNity
A Randomized Controlled Trial of Standard or DHA/EPA Supplemented Enteral Nutrition in Patients Undergoing Laparoscopic Colorectal Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Bowel cancer is the second most common cause of cancer-related death in the UK, with 50,000 new cases and over 15,000 deaths annually. Surgery is the mainstay of treatment and the most common complications are an infection of the wound or lungs. These can lengthen hospital stay, reduce the quality of life, and even increase the risk of death. Bowel cancer patients are often malnourished. Optimising nutrition with supplements such as fish-oils can improve the immune response of patients, helping prevent such complications, shorten hospital stay, improve quality of life and overall survival.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Complication, Postoperative | — | UNRESOLVED | — |
| Infected Wound | — | UNRESOLVED | — |
| Nutritional Deficiency | — | UNRESOLVED | — |
| Phagocytic Dysfunction | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
| Surgery--Complications | — | UNRESOLVED | — |
| Surgical Site Infection | — | UNRESOLVED |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Omega-3 | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Control
- description
- Patients undergoing standard laparoscopic colorectal resection with no omega-3 enriched peri-operative nutritional support
- type
- EXPERIMENTAL
- label
- Omega-3
- description
- Patients in this group will receive 7 days pre and 7 days post surgery of a nutritional supplement enriched with 1.42g/dose of the fish oils EPA and DHA. The supplement is pre-mixed and will be taken twice daily for a total of 14 days.
- interventionNames
- Dietary Supplement: Omega-3
Primary outcomes (2)
- measure
- Changes in Phagocytosis of pathogens
- timeFrame
- Baseline [2-4 weeks before surgery], Day of Surgery [day 7 post nutritional supplementation], Day 1 post surgery [day 8 post supplementation].
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with colorectal cancer undergoing elective laparoscopic colorectal resection. * Adult aged 18 or over. * Capacity to consent Exclusion Criteria: * Pre-existing diagnosis of Diabetes mellitus, requiring medication. * Consumption of \> 3 alcoholic drinks/day * Already on omega-3 supplementation * Pregnant * Patients on heparin infusion perioperatively * Patients on immunosuppressive drugs * Regular / Daily smokers * Patients requiring a blood transfusion at any point day 7 pre-op to day 1 post operatively. * Vegan or Vegetarian * Allergy to cows milk or wheat
References
Publications (0)
Data not yet available