Clinical trial · Observational
The Detection of Barrett's Esophagus by Gastrointestinal Endoscopy Prevents Esophageal Carcinoma in Morbid Obese After Sleeve Gastrectomy
Refleeve : A Retrospective Study to Evaluate the Prevalence of the Barett's Esophagus by Gastro-osephagal Endoscopy in Morbid Obese Patients Treated by Sleeve Gastrectomy and the Advantage of the Systematic Detection in the Prevention of Esophageal Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Severe Gastroesophageal reflux disease (GERD) leading to a chronic aggression of esophagus mucosa, called Barrett's esophagus is a main complication of Sleeve gastrectomy for morbid obesity. Barrett's esophagus is considered as a early stage of neoplastic transformation to adenocarcinoma. Since this last years, six european bariatric centers have adopted the policy to realize endoscopy before and five years or more after sleeve gastrectomy. Investigators worked out a database comprizing the Endoscopic features and patient characteristics. Refleeve projet aim to analyse the long term follow-up datas of 100 patients, evaluate the prevalence of Barret's esophagus and investigate the advantage of the systemetic detection to prevent esophagus adenocarcinomas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastroesophageal Reflux | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Sleeve gastrectomy
- timeFrame
- 5 years
- description
- Gastroesophageal endoscopic features before and five years after sleeve gastrectomy
Secondary outcomes (1)
- measure
- Obesity related comorbidity
- timeFrame
- 5 years
- description
- obesity related comorbidity before and five years or more after sleeve gastrectomy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who had had SG with a minimum follow-up of 5 years, without signs of Barrett's esophagus before SG; * An upper GI endoscopy before the SG; * An upper GI endoscopy indicating that no Barrett's esophagus was present at the time of the SG; * An upper GI endoscopy done with the scope of searching for the endoscopic anomalies of the Barrett's esophagus according to the international guidelines for the diagnosis of Barrett's esophagus 9. * Endoscopic biopsies according to the international guidelines for the diagnosis of Barrett's esophagus 9. Exclusion Criteria: * SG as a conversional procedure from another bariatric procedure such as the gastric banding; * No upper GI endoscopy before the SG * Barrett's esophagus before the SG; * A second procedure after the SG such as the conversion to Roux-en-Y gastric bypass or duodenal switch; * An upper GI endoscopy done not following the international guidelines for the diagnosis of Barrett's esophagus9.
References
Publications (1)
- RESULTBulsei J, Chierici A, Alifano M, Castaldi A, Drai C, De Fatico S, Rosso E, Fontas E, Iannelli A. Bariatric surgery reduces the risk of pancreatic cancer in individuals with obesity before the age of 50 years: A nationwide administrative data study in France. Eur J Surg Oncol. 2023 Apr;49(4):788-793. doi: 10.1016/j.ejso.2022.11.013. Epub 2022 Nov 9. PMID 36376141