Clinical trial · Interventional
Effect of Remote Ischaemic preConditioning on Liver Injury in Patients Undergoing LIVER Resection Surgery
Effect of Remote Ischaemic preConditioning on Liver Injury in Patients Undergoing LIVER Resection Surgery: The ERIC-LIVER Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Liver resection has improved health outcomes in patients with hepatocellular carcinoma (HCC) in Singapore and worldwide. However, due to acute ischaemia/reperfusion injury (IRI) to the liver at the time of surgery, patients still experience significant morbidity and mortality. Therefore, novel therapies are required to protect the liver against acute IRI during partial hepatectomy. Remote ischaemic conditioning (RIC) using transient limb ischaemia/reperfusion has been shown to protect the liver in experimental animal studies. In the ERIC-LIVER trial the investigators investigate whether RIC can reduce liver injury and preserve liver function in patients with HCC undergoing partial hepatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Cancer | Hepatocellular Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Active RIC | Device | — | UNRESOLVED |
| Sham Control | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Active RIC
- description
- Active RIC using a manual BP cuff to inflate to 200mmHg.
- interventionNames
- Device: Active RIC
- type
- SHAM_COMPARATOR
- label
- Sham Control
- description
- A sham control using a manual blood pressure cuff visually identical to that used in the RIC protocol will be placed on the upper arm and a simulated RIC protocol will be administered.
- interventionNames
- Device: Sham Control
Primary outcomes (2)
- measure
- serum ALT (unit/L) following liver resection, measured at 24 hours
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 21 years and above * Patients undergoing partial hepatectomy for primary HC Exclusion Criteria: * Patients with significant pulmonary disease (FEV1\<40% predicted). * Patients with known severe renal failure with a GFR\<30 mL/min/1.73 m2. * Patients on sulphonylurea or nicorandil, as these medications may interfere with the protective effect of RIC. * Patients recruited into another study which may impact on this study. Significant peripheral arterial disease affecting the upper limbs. * Patients undergoing repeat liver resection surgery.
References
Publications (0)
Data not yet available