Clinical trial · Interventional
Effects of Anesthetic Methods on Hepatic Cancer Cell Malignancy
Effects of Serum From Hepatocellular Carcinoma Surgery Patients Under Different Anesthetic Methods on Hepatic Cancer Cell Malignancy in Vitro
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Numerous studies found that anesthetic methods can influence the recurrence of tumor and the overall survival of patients after primary cancer surgery. Radiofrequency (RF) ablation is now widely used in clinic for treatment of hepatocellular carcinoma (HCC). Currently, diverse anesthetic methods, including general anesthesia (GA), epidural anesthesia and local anesthesia (LA), are used for RF ablation surgery. Using serum from HCC surgery patients randomized to receive either GA or LA during surgery, we investigated the effects of anesthetic methods on proliferation, migration and metastasis in HepG2 hepatic cancer cells in vitro.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| anesthetic methods | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- general anesthesia
- description
- Patients in this group will have RF ablation for treatment of HCC under general anesthesia.
- interventionNames
- Procedure: anesthetic methods
- type
- ACTIVE_COMPARATOR
- label
- local anesthesia
- description
- Patients in this group will have RF ablation for treatment of HCC under local anesthesia.
- interventionNames
- Procedure: anesthetic methods
Primary outcomes (1)
- measure
- cell proliferation
- timeFrame
- 1 hour post-surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients with a single primary liver tumor of 3cm or smaller, who are scheduled for RF ablation surgery Exclusion Criteria: * less than 18 or more than 65 years old; * ASA Physical Status 4 or greater; * previous surgery in liver (including radiofrequency ablation); * severe systemic disease (heart, lung, kidney, or immune system); * INR\>1.5 or platelet count \<45,000 cells/mm3; * a history of addiction to opioids; * with known extension beyond the liver; * Child-Pugh Class C.
References
Publications (1)
- DERIVEDNunez-Rodriguez E, Zhang H, Sah D, Cata JP. Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? Adv Biol (Weinh). 2025 Oct;9(10):e00122. doi: 10.1002/adbi.202500122. Epub 2025 Aug 7. PMID 40772525