Clinical trial · Observational
A Study of Circulating Exosome Proteomics In Gallbladder Carcinoma Patients
NCT03581435CI-TRIAL-00033694EXOGBC001unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research will be the first study for exosome purified from blood in gallbladder carcinoma patients. Proteomics studies will be done in both tumor tissue and the circulating exosome from blood specimens. Then, the potential prognostic and predictive biomarkers will be searched by bioinformatics to find the correlations between exosome biomarkers and gallbladder carcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gallbladder Carcinoma | Gallbladder Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Proteinosis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- gallbladder carcinoma patients
- description
- Cases will be the patients with newly-diagnosed gallbladder carcinoma.
- label
- The controls
- description
- The controls will be matched （1：1）by sex，race and age which will be selected from the patients receiving cholecystectomy due to gallstones from the same hospital with the cases.
Primary outcomes (2)
- measure
- Characterization of the protein profile in tumor derived exosomes from the gallbladder carcinoma patients
- timeFrame
- Up to 2 years from start of study
- description
- Proteomics studies will be done in both tumor tissue and the circulating exosomes from blood specimens. The specific protein A in the circulating exosomes from the gallbladder carcinoma patients will be selected for further analysis.
- measure
- The expression of protein A in the circulating exosomes from patients
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with gallbladder carcinoma by imaging tests (cases) Diagnosed with chronic cholecystitis by imaging tests (hospital controls) Exclusion Criteria: * The pathology diagnosis and imaging does not matched Patients with other malignant tumors Patients with other severe systemic diseases
References
Publications (0)
Data not yet available
No reference posted for this study.