Clinical trial · Observational
Postural Control Under Different Cognitive Loads in Adult Survivors of Acute Lymphoblastic Leukemia and Age-Matched Healthy Individuals
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine if adult survivors of childhood Acute Lymphoblastic Leukemia (ALL) enrolled on the SJLife (St. Jude Life) protocol are at increased risk for postural control deficits compared to individuals with no cancer history. All participants will be assessed for their ability to maintain an upright posture, walk at their usual speed, and to tandem walk, all while engaged in a cognitive task. Primary Objective To compare changes in postural control in ALL survivors to changes in postural control in healthy controls, matched on age- and sex- in simple versus complex standing and walking activities (complex: standing or walking with added cognitive load). Secondary Objective To identify demographic and performance related risk factors for decreased postural control during complex standing or walking activities in survivors and controls and to evaluate associations between treatment and the changes in postural control during complex activities among survivors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- ALL Survivors
- description
- Adult survivors of Acute Lymphoblastic Leukemia (ALL) enrolled on the SJLIFE protocol
- label
- Control Group
- description
- Healthy Individuals with no history of childhood or adult onset cancer, matched on age- and sex
Primary outcomes (2)
- measure
- Regular gait speed
- timeFrame
- Up to 1 hour
- description
- Regular gait will be evaluated in three different testing conditions: regular gait assessment while participants are engaged in performing a challenging cognitive task (2-back), regular gait assessment while participants are engaged in performing an easy cognitive task (0-bak) and regular gait assessment with no additional cognitive load (baseline). In each condition, the difference in gait speed of each survivor and his/her matched control will be obtained. Then the obtained differences at regular gait assessment with no additional cognitive load (baseline) and regular gait while performing the challenging cognitive task (2-bck) will be compared using a paired t-test.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 39 Years
Show eligibility criteria text
Inclusion Criteria - Cases: * Diagnosis of childhood ALL * At least 5 years post ALL diagnosis * No history of secondary malignancies after an ALL diagnosis * Enrollment on the SJLIFE protocol * Ages 18.00 to 39.99 * Ability to stand and walk for 20 seconds or more * Ability to answer the eligibility questions * Ability to provide informed consent Inclusion Criteria - Controls: * No history of childhood or adult onset cancer * Enrollment on the SJLIFE protocol * Ages 18.00 to 39.99 * Ability to stand and walk for 20 seconds or more * Ability to answer the eligibility questions * Ability to provide informed consent Inclusion of Women and Minorities: • Male and females of all races and ethnic groups are eligible Exclusion Criteria: * Currently receiving treatment for cancer * Weight ≥ 300 lb (the balance system has a weight limit) * Does not speak English * Self-reports of hearing issues * Pregnant females * Inability or unwillingness of research participant to give written informed consent.
References
Publications (0)
Data not yet available