Clinical trial · Interventional
Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture?
NCT03580213CI-TRIAL-00069840completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for Dupuytren's contracture. Differences on this between patients with contracted proximal interphalangeal joint(s) and patients with affected metacarpophalangeal joint(s) only, will also be investigated. Two equal sized groups will either receive hand therapy or no treatment following the injection and extension procedure.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dupuytren Disease of Palm and Finger, With Contracture | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hand therapy MCPJ affected | Other | — | UNRESOLVED |
| Hand therapy PIPJ affected | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Hand therapy MCPJ affected
- description
- 40 participants With Dupuytren's contracture with only the Metacarpophalangeal joints affected, receiving hand therapy after collagenase injection and extension treatment. Hand therapy: edema control, wound and scar treatment, splinting, exercises for hand, exercise through activities of daily living.
- interventionNames
- Other: Hand therapy MCPJ affected
- type
- EXPERIMENTAL
- label
- Hand therapy PIPJ affected
- description
- 40 participants With Dupuytren's contracture with the proximal interphalangeal joint involved, receiving hand therapy after collagenase injection and extension treatment. Hand therapy: edema control, wound and scar treatment, splinting, exercises for hand, exercise through activities of daily living. Possible additional splint and exercises specifically for the PIPJ extension.
- interventionNames
- Other: Hand therapy PIPJ affected
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * patients treated with collagenase injection and extension procedure for Dupuytren's contracture Exclusion Criteria: * earlier injury or treatment for Dupuytren's contracture in the same finger * patients not capable of following a therapy program * before randomisation: infection or an allergic reaction to the drug or Complex regional pain syndrome arising * earlier participation in the same study makes the participant not eligible to be included once more when treated in the other hand.
References
Publications (1)
- DERIVEDAglen T, Matre KH, Lind C, Selles RW, Assmus J, Taule T. Hand therapy or not following collagenase treatment for Dupuytren's contracture? Protocol for a randomised controlled trial. BMC Musculoskelet Disord. 2019 Aug 28;20(1):387. doi: 10.1186/s12891-019-2712-z. PMID 31455312