Clinical trial · Interventional
SmART Heart: Study of mHealth Apps to Reduce Cancer-Treatment Effects on the Heart
NCT03574012CI-TRIAL-00073189completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot trial studies how well education and mobile health applications work in reducing the effects of cancer treatment on the heart in participants with blood cancers that are in remission. Education and mobile health applications may be effective ways to manage heart health and to reduce future heart disease risk in participants with blood cancers.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Leukemia in Remission | Acute Leukemia | CURATED_BROADER | 0.78 |
| Hematopoietic Cell Transplantation Recipient | — | UNRESOLVED | — |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Informational Intervention | Other | — | UNRESOLVED |
| Monitoring Device | Device | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Control Group (general health information, fitness tracker)
- description
- Participants receive general information about physical activity and diet, and access to Fitbit and Healthwatch.
- interventionNames
- Device: Monitoring Device
- Other: Informational Intervention
- Other: Questionnaire Administration
- type
- EXPERIMENTAL
- label
- Intervention Group (individualized information, tracker)
- description
- Participants receive individualized goal-setting and coaching in relation to physical activity and diet, supplemented with peer support through the study's social media platform, over 4 months. They also have access to mHealth apps including Fitbit and Healthwatch that provide feedback on physical activity and diet.
- interventionNames
- Device: Monitoring Device
- Other: Informational Intervention
- Other: Questionnaire Administration
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: * Prior diagnosis of an acute leukemia or lymphoma or any receipt of HCT for a malignant condition. * At time of approach, \>= 5 years from initial cancer diagnosis or \>= 5 years from first HCT, whichever is later. * Currently in remission and not on any active anti-cancer therapies (survivors receiving maintenance tyrosine kinase inhibitors are NOT eligible). * Able to read, write, and speak English. * Access to smart phone or computer with internet access. * Presence of at least 1 CV risk factor: * Currently on medication for hypertension, or * Currently on medication for cholesterol or triglyceride, or * Currently on medication for diabetes, or * Currently not physically active (self-reported average \< 30 minutes/day), or * Currently smoking. * Ability to understand and the willingness to provide informed consent. Exclusion Criteria: * Pre-existing ischemic heart disease (includes angina if documented in electronic medical record \[EMR\]) or ongoing symptomatic cardiomyopathy (those with asymptomatic cardiomyopathy may be allowed to participate if they do not have any current activity restrictions, but we will seek physician clearance for any submaximal exercise testing). * Active systemic treatment for graft versus host disease. * Currently pregnant. However, participants enrolled who become pregnant after randomization can remain on the study.
References
Publications (1)
- RESULTChow EJ, Doody DR, Di C, Armenian SH, Baker KS, Bricker JB, Gopal AK, Hagen AM, Ketterl TG, Lee SJ, Reding KW, Schenk JM, Syrjala KL, Taylor SA, Wang G, Neuhouser ML, Mendoza JA. Feasibility of a behavioral intervention using mobile health applications to reduce cardiovascular risk factors in cancer survivors: a pilot randomized controlled trial. J Cancer Surviv. 2021 Aug;15(4):554-563. doi: 10.1007/s11764-020-00949-w. Epub 2020 Oct 10. PMID 33037989