Clinical trial · Observational
Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma
The Clinical Study of Radiation-associated Carotid Artery Disease in Patients With Nasopharyngeal Carcinoma Treated by IMRT
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke. Currently, little is known about the incidence of radiation-associated carotid vasculopahty in the context of intensity-modulated radiation therapy (IMRT). The aim of this study is to determine whether IMRT will increase the incidence of carotid vasculopathy in patients with nasopharyngeal carcinoma (NPC).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carotid Artery Diseases | — | UNRESOLVED | — |
| Nasopharyngeal Carcinoma | Nasopharyngeal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Carotid Color Flow Duplex Testing | Diagnostic Test | — | UNRESOLVED |
| Detection and measurement of carotid plaques | Diagnostic Test | — | UNRESOLVED |
| Measurement of intima media thickness of carotid artery | Diagnostic Test | — | UNRESOLVED |
| Medical history of cardiovascular risk factors and cardiovascular diseases | Other | — | UNRESOLVED |
| Montreal Cognitive Assessment | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- the post-radiation group
- description
- patients diagnosed as non-metastatic nasopharyngeal carcinoma who received definitive IMRT more than 3 years ago
- interventionNames
- Diagnostic Test: Measurement of intima media thickness of carotid artery
- Diagnostic Test: Detection and measurement of carotid plaques
- Diagnostic Test: Carotid Color Flow Duplex Testing
- Diagnostic Test: Montreal Cognitive Assessment
- Other: Medical history of cardiovascular risk factors and cardiovascular diseases
- label
- the pre-radiation group
- description
- untreated patients diagnosed as non-metastatic nasopharyngeal carcinoma
- interventionNames
- Diagnostic Test: Measurement of intima media thickness of carotid artery
- Diagnostic Test: Detection and measurement of carotid plaques
- Diagnostic Test: Carotid Color Flow Duplex Testing
- Diagnostic Test: Montreal Cognitive Assessment
- Other: Medical history of cardiovascular risk factors and cardiovascular diseases
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * signed inform consent * age more than 18 years old * ECOG 0-2 * pathologic diagnosed, non-metastatic NPC * either untreated or treated by definitive IMRT 3 years ago * did not receive radiation to the head and neck region prior to the diagnosis of NPC * if the patient received definitive IMRT 3 years ago because of NPC, he or she did not receive a second course of radiation due to local relapse * no prior surgery of head and neck Exclusion Criteria: * prior history of cardiovascular disease before the diagnosis of NPC * prior radiation to head and neck before the diagnosis of NPC * prior surgery of head and neck * pregnant or lactating women
References
Publications (0)
Data not yet available