Clinical trial · Interventional
Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine
Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine in Major Abdominal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining its effect for acute pain. The objective of this study is to evaluate the analgesic effect of duloxetine combined with intrathecal morphine for patients subjected to major abdominal cancer surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Duloxetine 60mg | Drug | — | UNRESOLVED |
| placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- duloxetine+morphine
- interventionNames
- Drug: Duloxetine 60mg
- type
- PLACEBO_COMPARATOR
- label
- placebo+morphine
- interventionNames
- Drug: placebo
Primary outcomes (1)
- measure
- time to first analgesic request
- timeFrame
- 48 hours postoperatively
- description
- the time elapsed from (0 hour = immediately postoperative) to time of first demand to analgesic
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * adult patients, subjected to major abdominal cancer surgery Exclusion Criteria: * patients on chronic opioid therapy * patients allergic to study drugs (duloxetine+morphine) * patients have uncontrolled hypertension and or ischemic heart disease
References
Publications (0)
Data not yet available