Study of BCMA CAR-T in Multiple Myeloma

Inclusion Criteria:

1. Male or female, 18 to 70 years old (including 18 and 70 years old)
2. BCMA antigen diagnosed by pathology and histological examination was positive
3. ECOG ≤2，and the excepted survival ≥ 3 months
4. Patients with BCMA+ myeloma who received ≥ 1 line of chemoradiotherapy or tumor relapsed
5. The main organs function is good; （1） liver function: ALT/AST\<3 times normal value upper limit (ULN) and total bilirubin \<34.2 (mol/L); （2） renal function: creatinine \<220 mu /L,GFR \> 30mL/min; （3） lung function: blood oxygen saturation is greater than 95%; （4） cardiac function: left ventricular ejection fraction (LVEF) is greater than 50%;
6. Platelets \> 40 billion/L;
7. Patients without any anti-cancer treatment such as chemotherapy，radiotherapy, immunotherapy（ immunosuppressive drugs ）within 2-4 weeks before, and the treatment-related toxicity reaction ≤1 level prior to enrollment（except low toxicity lose hair for example）
8. Venous channel is unobstructed, which can meet the needs of intravenous drip;
9. Voluntary informed consent is given, agree to follow the trial treatment and visit plan.

Exclusion Criteria:

1. Patients with allergy to large molecules such as antibodies or cytokines;
2. More than 5mg of hormones (except patients with inhaled hormone) were used within 2 to 4 weeks prior enrollment;
3. Patients with severe autoimmune diseases or immunodeficiency diseases;
4. Patients treated with other immune cellular products (DC, CIK, T, NK, and CART products with CD19 or other targets);
5. Patients with uncontrollable infectious disease in the first 4 weeks of treatment;
6. Active hepatitis B DNA \> 1000copy/mL/ , hepatitis C positive, (HCV positive resistance, HCV RNA positive);
7. Patients participated in other clinical trials within 6 weeks prior enrollment;
8. Patients with mental illness;
9. Patients with drug abuse/addiction and medical, psychological or social conditions may interfere with the study or evaluate the results of the study;
10. Patients have alcohol dependence;
11. Pregnant or lactating women; Men or women who have a pregnancy plan within a year; The patients cannot guarantee effective contraceptive measures during the trial period;
12. Patients had other conditions that were not appropriate for the group determined by the researchers.