Clinical trial · Observational
Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies
Monitoring of Immune and Microbial Reconstitution in Hematopoietic Cell Transplantation (HCT) and Novel Immunotherapies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Accrual goal met
Summary
Brief summary (as posted)
This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center in order to conduct correlative studies of the immune system, microbiota, and their interactions. Fluid (including but not limited to, blood, urine, saliva, cerebrospinal fluid, bronchoalveolar lavage fluid) sample log-in, processing, relabeling, and storage is performed by the Masonic Cancer Center (MCC) Translational Therapy Lab (TTL).
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute-graft-versus-host Disease | — | UNRESOLVED | — |
| Allogenic Related Donors | — | UNRESOLVED | — |
| Cell Therapy/Immunotherapy Patients | — | UNRESOLVED | — |
| Chronic Graft-versus-host-disease | — | UNRESOLVED | — |
| Cytokine Release Syndrome | — | UNRESOLVED | — |
| Immune and Microbial Reconstitution | — | UNRESOLVED | — |
| Recurrent Malignancy | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Systemic Viral Infection | — | UNRESOLVED | — |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Apheresis Product | Diagnostic Test | — | UNRESOLVED |
| Blood Sample | Diagnostic Test | — | UNRESOLVED |
| Bronchoalveolar Lavage (BAL) fluid | Diagnostic Test | — | UNRESOLVED |
| Final cellular product | Diagnostic Test | — | UNRESOLVED |
| Gastrointestinal biopsy x 2-4 | Diagnostic Test | — | UNRESOLVED |
| Skin biopsy | Diagnostic Test | — | UNRESOLVED |
| Skin, mouth, and/or ocular swab | Diagnostic Test | — | UNRESOLVED |
| Stool Sample | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (8)
- label
- Immune and Microbial Reconstitution
- interventionNames
- Diagnostic Test: Blood Sample
- Diagnostic Test: Stool Sample
- Diagnostic Test: Urine Sample
- label
- Immune Response Triggered by Severe, Systemic Viral Infection
- interventionNames
- Diagnostic Test: Blood Sample
- Diagnostic Test: Bronchoalveolar Lavage (BAL) fluid
- label
- Immune Response Triggered by Acute Graft-versus-Host Disease
- interventionNames
- Diagnostic Test: Blood Sample
- Diagnostic Test: Stool Sample
- Diagnostic Test: Gastrointestinal biopsy x 2-4
- Diagnostic Test: Skin biopsy
- label
- Immune Response Triggered by Chronic Graft-versus-Host Disease
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients planning to undergo HCT or other cellular therapy/immunotherapy * Allogeneic related donors * Aged 0-80 * Willing and able to sign voluntary written consent Exclusion Criteria: * Patients whose medical record indicates that they have opted out of research
References
Publications (0)
Data not yet available