Clinical trial · Interventional
USG PECS vs LIA for Breast Cancer Surgery
Ultrasound Guided (USG) PECS Versus Local Infiltration Anaesthesia (LIA) for Breast Cancer Surgery - A Randomized Quadruple Blinded Efficacy and Safety Study
NCT03555227CI-TRIAL-00035978completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Breast cancer is the most common cancer for which women in the UK (United Kingdom) undergo surgery. A novel ultrasound guided regional anaesthetic technique called the 'Pecs 2' block has recently been described. This study compares ultrasound guided (USG) Pecs 2 block with local anaesthetic infiltration (LIA) for pain relief following breast cancer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer Female | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| USG PECS2 with Drug A (active) | Procedure | — | UNRESOLVED |
| USG PECS2 with Drug P (placebo) | Procedure | — | UNRESOLVED |
| Wound infiltration with Drug A (active) | Procedure | — | UNRESOLVED |
| Wound infiltration with Drug P (placebo) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group X
- description
- PECS group USG PECS2 with Drug A (active) Wound infiltration with Drug P (placebo)
- interventionNames
- Procedure: USG PECS2 with Drug A (active)
- Procedure: Wound infiltration with Drug P (placebo)
- type
- ACTIVE_COMPARATOR
- label
- Group Y
- description
- LA (local anaesthetic) infiltration group USG PECS2 with Drug P (placebo) Wound infiltration with Drug A (active)
- interventionNames
- Procedure: USG PECS2 with Drug P (placebo)
- Procedure: Wound infiltration with Drug A (active)
Primary outcomes (2)
- measure
- Morphine consumption in Recovery
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: * Adult female breast cancer patients * Admitted to Craigavon Area Hospital * Requiring and undergoing elective/urgent unilateral breast surgery as set out in the protocol Exclusion Criteria: * Patient allergic to local anaesthetic * Any condition precluding safe use of USG pecs blocks e.g. Infection at site, anatomical abnormality etc. * Preoperative chronic pain and or on pain medication over and above simple analgesics. Patients receiving any analgesia other than paracetamol, NSAIDS and codeine shall be excluded from the study. * Bilateral breast surgery * Consent declined
References
Publications (19)
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- BACKGROUNDBundred N, Maguire P, Reynolds J, Grimshaw J, Morris J, Thomson L, Barr L, Baildam A. Randomised controlled trial of effects of early discharge after surgery for breast cancer. BMJ. 1998 Nov 7;317(7168):1275-9. doi: 10.1136/bmj.317.7168.1275. PMID 9804712
- BACKGROUNDPurushotham AD, McLatchie E, Young D, George WD, Stallard S, Doughty J, Brown DC, Farish C, Walker A, Millar K, Murray G. Randomized clinical trial of no wound drains and early discharge in the treatment of women with breast cancer. Br J Surg. 2002 Mar;89(3):286-92. doi: 10.1046/j.0007-1323.2001.02031.x. PMID 11872051
- BACKGROUNDBonnema J, van Wersch AM, van Geel AN, Pruyn JF, Schmitz PI, Uyl-de Groot CA, Wiggers T. Cost of care in a randomised trial of early hospital discharge after surgery for breast cancer. Eur J Cancer. 1998 Dec;34(13):2015-20. doi: 10.1016/s0959-8049(98)00258-5. PMID 10070303
- BACKGROUNDExadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology. 2006 Oct;105(4):660-4. doi: 10.1097/00000542-200610000-00008. PMID 17006061
- BACKGROUNDSacerdote P, Bianchi M, Gaspani L, Manfredi B, Maucione A, Terno G, Ammatuna M, Panerai AE. The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients. Anesth Analg. 2000 Jun;90(6):1411-4. doi: 10.1097/00000539-200006000-00028. PMID 10825330
- BACKGROUNDYeager MP, Colacchio TA, Yu CT, Hildebrandt L, Howell AL, Weiss J, Guyre PM. Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers. Anesthesiology. 1995 Sep;83(3):500-8. doi: 10.1097/00000542-199509000-00008.