Clinical trial · Observational
4D Cone Beam CT Reconstruction for Radiotherapy Via Motion Vector Optimization
NCT03551405CI-TRIAL-00046714terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To validate a new 4D Cone Beam CT (4DCBCT) reconstruction algorithm that was developed in our research group recently in terms of its geometry and intensity accuracy through real patient studies. Dose calculation found out in this study will not be used on the subject
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CBCT scan | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Intensity accuracy
- description
- The difference of the HU values in corresponding ROIs in the two image sets will be compared with zero using one sample t-test. In addition, we will also use these patient cases to test the computational efficiency of our algorithm. Based on our preliminary study, it is expected that the computation time will be 5\~10 sec per phase. The reconstruction time will be recorded in these patient cases and will be assessed.
- interventionNames
- Radiation: CBCT scan
Primary outcomes (1)
- measure
- Potential Benefits:
- timeFrame
- 10 years
- description
- There is no direct benefit from the study to the subjects. All participants will be clearly informed about this. The individual patient's treatment will not be changed based on the data collected from these procedures.The study will use the CTCAE version 4.0 for reporting of acute and late adverse events related to Lung will be reported by the physician through exam/assessment during research visit, encompassing events since last research visit. Upon completion, the project will lead to an accurate and safe 4DCBCT imaging procedure for patient positioning to facilitate lung IGRT treatment.where the image quality is much improved compared to current standard 4DCBCT method and the scan time and hence radiation dose is greatly reduced.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients that have been diagnosed with lung cancer, and are treated at Department of Radiation Oncology, UTSW. 2. Patients are greater than 18 years of age. 3. Patients understand a written informed consent document and are willing to sign the consent form. Exclusion Criteria: 1. Women who are pregnant or trying to get pregnant 2. Children (under age of 18)
References
Publications (0)
Data not yet available
No reference posted for this study.