Clinical trial · Interventional
Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.
NCT03549546CI-TRIAL-00039745POIRcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood samples | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients undergoing lung cancer surgery
- description
- Patients undergoing lung cancer surgery will be included. Blood samples will be collected.
- interventionNames
- Biological: Blood samples
Primary outcomes (1)
- measure
- PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes
- timeFrame
- Days 0, 1, 3
- description
- Correlation between expression of PD-1, TIM-3, CTLA4 on CD4/CD8 lymphocytes and the occurrence of lymphopenia. Measured by blood sample before lung cancer surgery, the next day lung cancer surgery and 3 days after lung cancer surgery. Analyzed by multicolour immunolabelling in flow cytometry
Secondary outcomes (2)
- measure
- functionality of CD4/CD8 lymphocytes and production of IF gamma, TNF and IL-2
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient ≥ 18 years undergoing lung cancer surgery by thoracoscopy Exclusion Criteria: * Patient under guardianship/curatorship * Patient who received of radiotherapy or chemotherapy in the last 6 months * Patient under immunosuppressive treatment or dose of corticoids over 10 mg/day prednisolone or equivalent * Patient with history of malignant blood disease or auto-immune disease * Patient suffering from HIV infection and * Patients with pre-operative infection * Patient with an empiric antibiotic therapy introduced at operating room
References
Publications (0)
Data not yet available
No reference posted for this study.