A Study of IBI310 for the Treatment of Patients With Advanced Solid Tumors.

Key Inclusion Criteria:

1. Patients with locally advanced, recurrent or metastatic solid tumors who failed standard treatment(applicable to the Ia period).
2. Patients with advanced, recurrent or metastatic melanoma confirmed by cytology or histology (applicable to the Ib period).
3. Signed written informed consent form and willing and able to comply with scheduled visits and other requirements of the study.
4. ≥18，and ≤70 years.
5. Life expectancy of at least 12 weeks.
6. At least 1 measurable lesion per RECIST v1.1(long axis\>15mm or short axis\>10mm)
7. Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-1.
8. Patients of reproductive potential must be willing to use adequate contraception during the course of the study and through 6 months after the last dose of study medication.
9. Adequate organ and bone marrow function.

Key Exclusion Criteria:

1. Prior exposure to any anti-CTLA-4, anti-PD-1 or anti-PD-L1/L2 antibody.
2. Received any investigational agent within 4 weeks of the first dose of study medication.
3. Received last dose of anti-tumor therapy (chemotherapy, endocrine therapy, targeted therapy, tumor immunotherapy or arterial embolization) within 4 weeks of the first dose of study medication.
4. Received treatment with corticosteroids (\>10mg daily prednisone equivalent) or other immunosuppressive medications within 4 weeks before the first dose of study medication. Nasal spray, inhalation, or other ways of topical corticosteroids or physiological doses of systemic corticosteroids are not included.
5. Received a live vaccine within 4 weeks of the first dose of study medication or plan to receive live vaccine during study period.
6. Active, known or suspected autoimmune disease or has a history of the disease within the last 2 years (Patients with vitiligo, psoriasis, alopecia or Grave's disease, hypothyroidism requiring hormone replacement, or type I diabetes mellitus only requiring insulin replacement, but not required systemic treatment in the last 2 years, are permitted to enroll)
7. Known primary immunodeficiency
8. Active tuberculosis
9. Known history of allogeneic organ or allogeneic hemopoietic stem cell transplantation
10. Known allergy or hypersensitivity to any other monoclonal antibodies or IBI310 and/or any components used in their preparation.
11. Known acute or chronic active hepatitis B (HBV DNA positive and HBV DNA copies ≥1×103/ml or ≥200IU/ml) infection or acute or chronic active hepatitis C (HCV antibody positive and HCV RNA positive) infection. Patients with HCV antibody positive but HCV RNA negative are permitted to enroll.
12. Patients with a history of interstitial lung disease
13. Uncontrolled third space effusion, eg. ascites or pleural effusion cannot be drained or controlled.
14. Women who are pregnant or nursing.