Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

* INCLUSION CRITERIA FOR CHILDREN:
* Patients diagnosed with a high-risk/high-grade cancer (e.g., high-grade brain tumors, relapsed/refractory acute lymphoblastic leukemia, acute myeloid leukemia, high-grade sarcoma) characterized by poor prognosis (e.g., estimated 5-year survival rate \<30% based on scientific consensus in the literature, where available, or by expert physician report), as confirmed by medical record review.
* Patients with active disease
* Age greater than or equal to 5 years and less than or equal to 24 years of age
* Must be able to speak and understand English.
* Must have a parent or adult primary caregiver willing to participate in the study.
* Ability of subject or parent/guardian to understand and the willing to sign a written informed consent document.
* Must have access to a computer/mobile device and the internet.

EXCLUSION CRITERIA FOR PATIENTS:

* Patients will be excluded if there is evidence of pre-morbid severe cognitive or psychiatric disability that would impair their capacity for participation or completion of evaluations in the judgment of the investigators.
* Evidence of disease progression at the time of referral to this study to the extent that it would impede participation or completion of evaluations as determined by the medical advisory investigator in conjunction with the study principal investigator (PI)/adjunct PI.
* Patients with treatment-related sequelae so severe that they would be unable to complete the study-related evaluations or intervention (e.g., treatment toxicity) as determined by the medical advisory investigator in conjunction with the study PI/adjunct PI.

INCLUSION CRITERIA FOR PARENT OR ADULT PRIMARY CAREGIVER:

* Must be a parent or primary caregiver of a child (age 5 to 24 years of age) who has been diagnosed with a high-grade/high risk tumor that carries poor prognosis (as defined above); and must live in the same household as the patient for a majority of the time.
* Must have a child willing to participate in the study
* Must be able to speak and understand English.
* Ability of subject to understand and the willing to sign a written informed consent document.
* Must have access to a computer/mobile device and the internet.