Expanded Access for PSV Personalized Oncolytic Viruses

Inclusion Criteria:

* Ability to understand and sign a written informed consent form.
* Measurable or evaluable disease with least one (1) tumor that is accessible to intratumoral injection.
* Eastern Cooperative Group (ECOG) performance status is 0-3 at Screening.
* Acceptable liver function at Screening, as evidenced by:

  * Bilirubin ≤ 3.0 X upper limit of normal (ULN) since this patient has
  * been diagnosed with Gilbert's Disease
* AST (SGOT) and ALT (SGPT) ≤ 5 X ULN.
* Serum creatinine \< 3 x institution upper limit of normal.
* Patient has acceptable hematologic status at Screening, as evidenced by:

  * Absolute neutrophil count ≥ 1,500 cells/mm3; and
  * Platelet count ≥ 70,000/mm3; and
  * Hemoglobin (HGB) ≥ 8.5 g/dL.
* Medically acceptable contraception.
* Willingness to comply with all protocol procedures, evaluations and rescue measures.

Exclusion Criteria:

* Presence of a serious co-morbid medical condition, or a clinically significant laboratory finding(s) that, in the opinion of the Investigator, suggests the presence of an infectious, endocrine, and/or other inadequately treated systemic disorder.
* An active bacterial, fungal, or viral infection.