Clinical trial · Interventional
The Oncoflavour Study
Product Validation by Cancer Patients - Oncoflavour
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Oral nutritional supplements (ONS) are often prescribed for malnourished patients to help improve nutritional status. Commonly in cancer patients taste and smell alterations and side effects of treatment can affect the palatability and compliance to ONS. A variety of flavours and styles are available of ONS however research of the palatability of these in cancer patients is limited. This study aims to evaluate specific flavours created based on the taste changes occuring during treatment. We aim to evaluate the patient liking and evaluation of 5 flavors in 3 different types of flavour-sensations: * Warming/spicy sensation: to trigger the senses and bring new sensations * Cooling/fresh sensation: to have a fresh mouthfeel and lighter base perception * Neutral: to avoid that patients experience additional flavour and let them the opportunity to mix it with other food
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tasting of flavours | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Taste of 5 flavors
- description
- * Each patient will taste 5 products, in sequential-monadic test, randomized, one by one. * Patients will take few sips of each study product, ideally in isolation (avoid influence of other patients) * For each product tasted the subjects will be asked to answer a questionnaire including 1 question on the palatability of the product using a 10-point hedonic scale and a more detailed organoleptic evaluation of the product. * Between product tastings, participants will have a 10 minutes break to rinse their mouth and fill in a questionnaire assessing sensory changes
- interventionNames
- Other: Tasting of flavours
Primary outcomes (1)
- measure
- Liking of 5 different oral nutritional supplements with adapted flavors
- timeFrame
- 20 minutes
- description
- To evaluate patient liking and perception about 5 new flavors on a 10-point scale via a sip test
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * \> 18 years old * Ability to complete and comprehend questionnaires provided * Undergoing systemic cancer treatment (chemotherapy or concurrent chemoradiotherapy, radiotherapy, targeted therapy or immunotherapy) Exclusion Criteria: * Uncertainty about the willingness or ability of the patient to comply with the protocol requirements (no impairment and no cognitive impairments) * Coexisting-morbidities affecting taste or smell function * Lactose Intolerance or Galactosaemia * Dysphagia * Diabetics * Food allergies/intolerances to ingredients present in the product * No rejection of lemon, red fruits, exotic fruit, yellow fruit flavours.
References
Publications (1)
- DERIVEDde Haan JJ, Renken RJ, Moshage Y, Kluifhooft DA, Corbier C, Daly LE, Blanchard H, Reyners AKL. Self-reported taste and smell alterations and the liking of oral nutritional supplements with sensory-adapted flavors in cancer patients receiving systemic antitumor treatment. Support Care Cancer. 2021 Oct;29(10):5691-5699. doi: 10.1007/s00520-021-06049-4. Epub 2021 Feb 25. PMID 33629188