Clinical trial · Observational
Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The principal investigator is leaving Yale University and will not be continuing the work at her new institution.
Summary
Brief summary (as posted)
The investigators' objective is to understand the pathogenesis of diabetes mellitus in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) by: 1) establishing the contributions of insulin resistance versus impaired insulin secretion, 2) investigating presence of excess glucagon signaling by measuring gluconeogenesis and glycogenolysis, and 3) investigating a potential interaction between diabetes and intraductal papillary mucinous neoplasms (IPMNs).
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Diabetes Mellitus | — | UNRESOLVED | — |
| Fibrous Dysplasia | Fibrous Dysplasia | ONTOLOGY_EXACT | 0.98 |
| Intraductal Papillary Mucinous Neoplasm | Pancreatic Intraductal Papillary Mucinous Neoplasm | ALIAS | 0.90 |
| McCune-Albright Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hyperglycemic Clamp | Procedure | — | UNRESOLVED |
| Hyperinsulinemic Euglycemic Clamp and 2H20 | Procedure | — | UNRESOLVED |
| Oral Glucose Tolerance Test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- label
- FD/MAS with diabetes mellitus
- description
- Fibrous Dysplasia/McCune-Albright Syndrome with diabetes mellitus. Participants will receive the following interventions: Hyperinsulinemic Euglycemic Clamp and 2H20; Hyperglycemic Clamp; and Oral Glucose Tolerance Test.
- interventionNames
- Procedure: Hyperinsulinemic Euglycemic Clamp and 2H20
- Procedure: Hyperglycemic Clamp
- Diagnostic Test: Oral Glucose Tolerance Test
- label
- FD/MAS without diabetes mellitus
- description
- Fibrous Dysplasia/McCune-Albright Syndrome without diabetes mellitus. Participants will receive the following interventions: Hyperinsulinemic Euglycemic Clamp and 2H20; Hyperglycemic Clamp; and Oral Glucose Tolerance Test.
- interventionNames
- Procedure: Hyperinsulinemic Euglycemic Clamp and 2H20
- Procedure: Hyperglycemic Clamp
- Diagnostic Test: Oral Glucose Tolerance Test
- label
- FD/MAS without diabetes and without IPMN
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) group: * Must be diagnosed based on clinical grounds and/or mutation testing on bone and/or affected tissue Control group: * Must be at least 18 years old Exclusion Criteria: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) group: * Unwilling to fully cooperate with the evaluation * Unable to provide informed consent Control group: * History of diabetes, insulin resistance, pancreatic disease, pancreatic cysts or amylase/lipase abnormality * Use of any type of oral diabetes medications and/or insulin * Unable to provide informed consent
References
Publications (0)
Data not yet available